Identification and bioactivity evaluation of ring-opening and lactone forms of enterolactone from sheep fed flaxseed cake

文献类型： 外文期刊

第一作者： Zhuang, Cong-Cong

作者： Zhuang, Cong-Cong;Liu, Chun-Rui;Xu, Hai-Yan;Yang, Xin-Yue;Wu, Dan-Dan;Zheng, Zhong;Wang, Li-Wei;Ma, Chao-Mei;Wang, Li-Wei;Liu, Zheng

作者机构：

关键词： Mammalian lignan; ring-opening enterolactone; pH dependent structure; breast cancer; anti-osteoporosis

期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.2； 五年影响因子：2.3 ）

ISSN： 1478-6419

年卷期： 2024 年

页码：

收录情况： SCI

摘要： The previously undescribed lactone ring-opening enterolactone and its sulphate were purified along with the lactone counterparts from the urine of dairy sheep fed flaxseed cake. The structures were determined by NMR and MS analyses. The ring-opening and lactone forms underwent mutual transformation with changes in pH and milk could protect the lactone form. Enterolactone exhibited more effective anti-proliferation activity on MDA-MB-231 breast cancer cells than its ring-opening counterpart, while the ring-opening enterolactone demonstrated more effective anti-osteoporosis activity than the lactone form. The results indicated the potential for targeting biological functions through pH and medium manipulation.

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