Dynamic Changes in the Splenic Transcriptome of Chickens during the Early Infection and Progress of Marek's Disease

文献类型： 外文期刊

第一作者： Dang, Lu

作者： Dang, Lu;Li, Hua-Wei;Zhang, Gai-Ping;Dang, Lu;Teng, Man;Li, Hua-Wei;Li, Hui-Zhen;Ma, Sheng-Ming;Zhao, Pu;Li, Xiu-Jie;Deng, Rui-Guang;Luo, Jun;Li, Hui-Zhen;Zhang, Gai-Ping;Ma, Sheng-Ming;Luo, Jun;Zhang, Gai-Ping

作者机构：

期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.379； 五年影响因子：5.133 ）

ISSN： 2045-2322

年卷期： 2017 年 7 卷

页码：

收录情况： SCI

摘要： Gallid alphaherpesvirus 2 (GaHV2) is an oncogenic avian herpesvirus inducing Marek's disease (MD) and rapid-onset T-cell lymphomas. To reveal molecular events in MD pathogenesis and tumorigenesis, the dynamic splenic transcriptome of GaHV2-infected chickens during early infection and pathogenic phases has been determined utilizing RNA-seq. Based on the significant differentially expressed genes (DEGs), analysis of gene ontology, KEGG pathway and protein-protein interaction network has demonstrated that the molecular events happening during GaHV2 infection are highly relevant to the disease course. In the 'Cornell Model' description of MD, innate immune responses and inflammatory responses were established at early cytolytic phase but persisted until lymphoma formation. Humoral immunity in contrast began to play a role firstly in the intestinal system and started at late cytolytic phase. Neurological damage caused by GaHV2 is first seen in early cytolytic phase and is then sustained throughout the following phases over a long time period. During the proliferative phase many pathways associated with transcription and/or translation were significantly enriched, reflecting the cell transformation and lymphoma formation. Our work provides an overall view of host responses to GaHV2 infection and offers a meaningful basis for further studies of MD biology.

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