Polyketide pesticides from actinomycetes

文献类型： 外文期刊

第一作者： Li, Shanshan

作者： Li, Shanshan;Xiang, Wensheng;Yang, Bowen;Tan, Gao-Yi;Ouyang, Li-Ming;Wang, Weishan;Zhang, Lixin;Qiu, Shiwen;Wang, Weishan;Qiu, Shiwen;Xiang, Wensheng;Wang, Weishan

作者机构：

期刊名称：CURRENT OPINION IN BIOTECHNOLOGY （ 影响因子：9.74； 五年影响因子：9.807 ）

ISSN： 0958-1669

年卷期： 2021 年 69 卷

页码：

收录情况： SCI

摘要： Natural product derived pesticides have increased in popularity worldwide because of their high efficacy, eco-friendly nature and favorable safety profile. The development of polyketide pesticides from actinomycetes reflects this increase in popularity in the past decades. These pesticides, which include avermectins, spinosyns, polynactins, tetramycin and their analogues, have been successfully applied in crop protection. Moreover, the advance of biotechnology has led to continuous improvement in the discovery and production processes. In this review, we summarize these polyketide pesticides, their activities and provide insight into their development. We also discuss engineering strategies and the current status of industrial production for these pesticides. Given that actinomycetes are known to produce a wide range of bioactive secondary metabolites, the description of pesticide development and high yield strain improvement presented herein will facilitate further development of these valuable polyketide pesticides from actinomycetes.

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