Crosstalk between the ancestral type VII secretion system ESX-4 and other T7SS in Mycobacterium marinum

文献类型： 外文期刊

第一作者： Wang, Yuchen

作者： Wang, Yuchen;Zhao, Guoping;Zhang, Lu;Wang, Yuchen;Tang, Yuting;Lin, Chen;Zhang, Junli;Jiang, Jun;Gao, Xiaoxiao;Li, Yao;Zhang, Lu;Zhang, Lu;Mai, Juntao;Liu, Jun

作者机构：

期刊名称：ISCIENCE （ 影响因子：6.107； 五年影响因子：6.233 ）

ISSN：

年卷期： 2022 年 25 卷 1 期

页码：

收录情况： SCI

摘要： The type VII secretion system (T7SS) of Mycobacterium tuberculosis secretes three substrate classes: Esx, Esp, and PE/PPE proteins, that play important roles in bacterial physiology and host interaction. Five subtypes of T7SS, namely ESX-1 to ESX-5, are present in M. tb. ESX-4 is the progenitor of T7SS but its function is not understood. We investigated the ESX-4 system in Mycobacterium marinum. We show that ESX-4 of M. marinum does not secrete its cognate substrates, EsxT and EsxU, under the concitions tested. Paradoxically, the deletion of eccC4, an essential component of ESX-4, resulted in elevated secretion of protein substrates of ESX-1 and ESX-5. Consequently, the Delta eccC mutant was more efficient in inducing actin cytoskeleton rearrangement, which led to enhanced phagocytosis by macrophages. Our results revel an intimate crosstalk between the progenitor of T7SS and its more recent duplication and expansion, and provide new insight into the evolution of T7SS in mycobacteria.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序