Molecular epidemiology of hydropericardium syndrome outbreak-associated serotype 4 fowl adenovirus isolates in central China

文献类型: 外文期刊

第一作者: Zhang, Teng

作者: Zhang, Teng;Zhang, Teng;Jin, Qianyue;Ding, Peiyang;Chai, Yongxiao;Li, Yafei;Liu, Xiao;Luo, Jun;Zhang, Gaiping;Chai, Yongxiao;Liu, Xiao;Zhang, Gaiping;Ding, Peiyang;Li, Yafei;Wang, Yinbiao;Jin, Qianyue;Zhang, Gaiping

作者机构:

关键词: Hydropericardium syndrome;Chicken;Molecular epidemiology;Serotype 4 fowl adenovirus

期刊名称:VIROLOGY JOURNAL ( 影响因子:4.099; 五年影响因子:3.719 )

ISSN: 1743-422X

年卷期: 2016 年 13 卷

页码:

收录情况: SCI

摘要: In several parts of China, there have been a large number of hydropericardium syndrome (HPS) outbreaks caused by serotype 4 fowl adenovirus (FAdV4) in broiler chickens since 2015. These outbreak-associated FAdV-4 strains were distinct from previous circulating strains which did not lead to severe HPS outbreaks. To better understand the molecular epidemiology of the currently circulating FAdV strains for effective diagnosis and treatment of HPS, we isolated 12 HPS outbreak-associated FAdV-4 strains from different regions in central China and investigated their molecular characteristics by performing phylogenetic analyses based on the hexon genes. Our results indicated the FAdV-4 strains in this study all belonged to serotype FAdV-4, species FAdV-C. And in comparison with ON1, KR5, MX-SHP95, PK-01, PJ-06 strains within the cluster where outbreak-associated FAdV-4 strains were located, the nucleotide sequence divergence were 1.31, 1.10, 1.42, 2.77 and 2.84%, respectively. Phylogenetic analyses revealed the hexon genes of the 12 outbreak-associated strains clustered to a relatively independent branch of the tree, and evolved from the same ancestor and we suggested that these outbreak-associated FAdV-4 strains originate from earlier strains in India.

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