Impairment of the Antibody-Dependent Phagocytic Function of PMNs through Regulation of the Fc gamma Rs Expression after Porcine Reproductive and Respiratory Syndrome Virus Infection

文献类型： 外文期刊

第一作者： Wan, Bo

作者： Wan, Bo;Bao, Dengke;Wang, Yinbiao;Zhang, Gaiping;Wan, Bo;Qiao, Songlin;Li, Peng;Jin, Qianyue;Liu, Yunchao;Bao, Dengke;Liu, Mingyang;Wang, Yinbiao;Zhang, Gaiping

作者机构：

期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）

ISSN： 1932-6203

年卷期： 2013 年 8 卷 6 期

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收录情况： SCI

摘要： Porcine reproductive and respiratory syndrome (PRRS) is identified as one of the most important etiological agents in multifactorial respiratory disease of swine and can predispose pigs to secondary infections by other pathogens, usually bacteria. To understand the mechanism for an increased susceptibility to secondary bacterial infections, we investigated the antibody-dependent phagocytosis behaviour and killing ability of PMNs after infection by PRRSV strains BJ-4 or HN07-1. PMN's antibody-dependent phagocytosis and their ability to kill E. coli were both noticeably decreased following PRRSV infection, in particular with the highly pathogenic strain HN07-1. As the change in this function of the PMNs may reflect a variation in the expression of Fc gamma Rs, the expression profiles of the activating and the inhibitory Fc gamma Rs were examined. We found that RNA expression of the inhibitory receptor Fc gamma RIIB was up-regulated post-infection, and this was greater after infection with the more virulent PRRSV strain HN07-1. The activating receptor Fc gamma RIIIA RNA expression was on the other hand inhibited to the same extent by both PRRSV strains. Neutralizing antibody titers post-infection by PRRSV strains BJ-4 or HN07-1 were also detected. All of the pigs in infection groups showed viraemia by the end of the study (56 DPI). These observations may help to understand the mechanism of increased susceptibility to secondary bacterial infections following PRRSV infection.

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