Cloning and characterization of ovine immunoglobulin G Fc receptor II (Fc gamma RII)

文献类型： 外文期刊

第一作者： Liu, Yunchao

作者： Liu, Yunchao;Qiao, Songlin;Zhang, Gaiping;Xi, Jun;You, Leiming;Tian, Xiaohui;Li, Qiaomu;Zhang, Lina;Guo, Junqing;Liu, Yunchao;Wang, Aiping

作者机构：

关键词： Sheep;Fc gamma RII;Inhibitory receptor;Expression

期刊名称：VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY （ 影响因子：2.046； 五年影响因子：2.217 ）

ISSN： 0165-2427

年卷期： 2010 年 133 卷 2-4 期

页码：

收录情况： SCI

摘要： Immunoglobulin G (IgG) Fc receptors (Fc gamma Rs) bind to immune complexes through interactions with the Fc region of IgG to initiate or inhibit the defense mechanism of the leukocytes on which they are expressed. In this study, we describe the cloning, sequencing and characterization of ovine Fc gamma RII. By screening a translated expression sequence tag (EST) database with the protein sequence of bovine IgG Fc receptor II, we identified a putative ovine homologue. Using rapid amplification of cDNA ends (RACE), we isolated the cDNA encoding ovine Fc gamma RII from peripheral blood leucocyte RNA. The ovine Fc gamma RII cDNA contains an 894 bp open-reading frame, encoding a 297 amino acid transmembrane glycoprotein composed of two immunoglobulin-like extracellular domains, a transmembrane region and a cytoplasmic tail with an immunoreceptor tyrosine-based inhibitory motif (ITIM). The glycoprotein encoded by the cloned cDNA was then expressed on the surface of COS-7 cells and immunoglobulin-binding assays show that it binds ovine IgG1, but not IgG2. Identification of the ovine Fc gamma RII will aid in the understanding of the molecular basis of IgG-Fc gamma R interaction. (C) 2009 Elsevier B.V. All rights reserved.

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