Characterization and ligand specificity of sheep IgG2 receptor

文献类型： 外文期刊

第一作者： Zhang, Gaiping

作者： Zhang, Gaiping;Qiao, Songlin;Zhang, Gaiping;Yang, Suzhen;Qiao, Songlin;Yang, Yanyan;Liu, Yunchao;Zhang, Gaiping;Xi, Jun;Zhang, Hong;Hao, Huifang;Tian, Xiaohui;Yang, Suzhen;Deng, Ruiguang

作者机构：

关键词： Cloning;Expression;Sheep;IgG;Fc Receptor

期刊名称：IMMUNOGENETICS （ 影响因子：2.846； 五年影响因子：2.814 ）

ISSN： 0093-7711

年卷期： 2009 年 61 卷 8 期

页码：

收录情况： SCI

摘要： Neutrophils and macrophages in cattle express a novel class of immunoglobulin Fc receptor, specific for bovine IgG2, termed boFc gamma 2R. In cows, the ability of neutrophils to kill immunoglobulin-opsonized microorganisms appears to depend largely on this subclass. Although related to other mammalian Fc gamma Rs, boFc gamma 2R belongs to a novel gene family that includes the human killer Ig-like receptor and Fc alpha RI (CD89) proteins. In this study, we describe the presence and characterization of this novel class of Fc gamma R in sheep. The comparative analysis of this novel Fc gamma R has allowed us to begin an exploration of some immunological characteristic of ruminants.

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