A novel hedgehog inhibitor iG2 suppresses tumorigenesis by impairing self-renewal in human bladder cancer

文献类型： 外文期刊

第一作者： Zhu, Lihong

作者： Zhu, Lihong;Shi, Yuefeng;Ni, Chen;Dong, Baijun;Zhang, Yong;Niu, Haitao;Li, Chong

作者机构：

关键词： Bladder cancer;Gli2;hedgehog;iG2

期刊名称：CANCER MEDICINE （ 影响因子：4.452； 五年影响因子：4.609 ）

ISSN： 2045-7634

年卷期： 2016 年 5 卷 9 期

页码：

收录情况： SCI

摘要： Tumor recurrence is still a major challenge for clinical treatment of bladder cancer. Cumulative evidences indicate cancer stem cells (CSCs) contribute to drug resistance and leave a putative source for disease relapse. Identifying novel agents targeting CSCs may represent a new paradigm in the therapy of bladder cancer. Here, we separated a novel hedgehog (Hh) inhibitor, iG2, from streptomyces roseofulvus, which dramatically blocked the activation of Gli2 in bladder cancer cells. The iG2 strongly repressed the growth of cancer cells rather than the peri-tumor stroma cells. Attenuated proliferation and enhanced apoptosis of tumor cells were observed upon iG2 stimulation. Furthermore, iG2 reduced the self-renewal ability of bladder CSCs as well as the tumor formation. Collectively, iG2 is potentially used as a novel therapeutic agent for bladder cancer by targeting self-renewal through inhibiting Hh pathway.

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