Differential Expression of miR-125a-5p and let-7e Predicts the Progression and Prognosis of Non-Small Cell Lung Cancer
文献类型: 外文期刊
第一作者: Le, Han-bo
作者: Le, Han-bo;Zhang, Yong-Kui;Zhu, Wang-Yu;Luo, Bin;He, Jian-ying;Chen, Dong-dong;Xu, Li-Yun;Huang, Yan-Yan;Liu, Xiao-Guang;An, Ji-yuan
作者机构:
关键词: miRNA;NSCLC;Early detection;Prognosis
期刊名称:CANCER INVESTIGATION ( 影响因子:2.176; 五年影响因子:2.344 )
ISSN: 0735-7907
年卷期: 2014 年 32 卷 8 期
页码:
收录情况: SCI
摘要: Aberrant expression of various microRNAs (miRNA) has shown diagnostic and prognostic significance in non-small cell lung cancer (NSCLC). qRT-PCR analysis confirmed altered expression of miR-125a-5p, let-7e, miR-30a, miR-30e andmiR-30e-3p in 70 paired tissue and serum samples from NSCLC patients. The reduced expression of miR-125a-5p, let-7e and miR-30e was strongly associated with NSCLC dedifferentiation. The lost expression of miR-125a-5p and let-7e was associated with shorter overall survival and let-7e was an independent prognostic factor for NSCLC patients. These five miRNA expressions should be further evaluated as biomarkers for the early detection and prognosis of NSCLC patients.
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