RNA interference of leptin receptor in chicken adipocytes

文献类型： 外文期刊

第一作者： Huang, A. X.

作者： Huang, A. X.;Fu, Y.;Wu, T. X.;Huang, A. X.;Li, J. J.;Tian, Y.;Shen, J. D.;Tao, Z. R.;Li, G. Q.;Lu, L. Z.

作者机构：

关键词： RNA interference;Leptin receptor;Chicken;Adipocyte;Lipid metabolism

期刊名称：GENETICS AND MOLECULAR RESEARCH （ 影响因子：0.764； 五年影响因子：0.912 ）

ISSN： 1676-5680

年卷期： 2014 年 13 卷 3 期

页码：

收录情况： SCI

摘要： In this study, chicken adipocytes were cultured to evaluate RNA interference by the leptin receptor gene. A small interfering RNA of the leptin receptor gene was synthesized, with a suppression rate of 60% being generated (P < 0.01). After the knockdown of the leptin receptor, the expression levels of certain genes decreased significantly; specifically, peroxisome proliferator-activated receptor gamma, fatty acid synthase, adipose triglyceride lipase, and lipoprotein lipase. In addition, a significant increase in the expression of the adiponectin gene was documented. These results demonstrate that the leptin receptor gene might contribute to lipid metabolism by influencing the expressions of the peroxisome proliferator-activated receptor gamma, fatty acid synthase, adipose triglyceride lipase, lipoprotein lipase, and adiponectin genes.

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