Cytotoxicity, oxidative stress, and genotoxicity in human hepatocyte and embryonic kidney cells exposed to ZnO nanoparticles

文献类型： 外文期刊

第一作者： Guan, Rongfa

作者： Guan, Rongfa;Kang, Tianshu;Liu, Mingqi;Lu, Fei;Zhang, Zhiguo;Shen, Haitao

作者机构：

关键词： ZnO nanoparticles;Cytotoxicity;Oxidative stress;Human hepatocyte;Human embryonic kidney cells

期刊名称：NANOSCALE RESEARCH LETTERS （ 影响因子：4.703； 五年影响因子：4.193 ）

ISSN： 1931-7573

年卷期： 2012 年 7 卷

页码：

收录情况： SCI

摘要： Traces of zinc oxide nanoparticles (ZnO NPs) used may be found in the liver and kidney. The aim of this study is to determine the optimal viability assay for using with ZnO NPs and to assess their toxicity to human hepatocyte (L02) and human embryonic kidney (HEK293) cells. Cellular morphology, mitochondrial function (MTT assay), and oxidative stress markers (malondialdehyde, glutathione (GSH) and superoxide dismutase (SOD)) were assessed under control and exposed to ZnO NPs conditions for 24 h. The results demonstrated that ZnO NPs lead to cellular morphological modifications, mitochondrial dysfunction, and cause reduction of SOD, depletion of GSH, and oxidative DNA damage. The exact mechanism behind ZnO NPs toxicity suggested that oxidative stress and lipid peroxidation played an important role in ZnO NPs-elicited cell membrane disruption, DNA damage, and subsequent cell death. Our preliminary data suggested that oxidative stress might contribute to ZnO NPs cytotoxicity.

分类号：

  • 相关文献

[1]Chemical Structures of Polyphenols That Critically Influence the Toxicity of ZnO Nanoparticles. Zhang, Cao,Li, Yining,Gong, Yu,Xie, Yixi,Cao, Yi,Liu, Liangliang,Cao, Yi. 2018

[2]Zinc Oxide Nanoparticles Influence Microflora in Ileal Digesta and Correlate Well with Blood Metabolites. Feng, Yanni,Min, Lingjiang,Zhang, Weidong,Chu, Meiqiang,Li, Lan,Shen, Wei,Zhao, Yong,Zhang, Hongfu,Liu, Jing,Hou, Zhumei,Zhao, Yong. 2017

[3]The Interactions between ZnO Nanoparticles (NPs) and alpha-Linolenic Acid (LNA) Complexed to BSA Did Not Influence the Toxicity of ZnO NPs on HepG2 Cells. Zhou, Yiwei,Fang, Xin,Xiao, Aiping,Liu, Liangliang,Cao, Yi,Zhou, Yiwei,Fang, Xin,Gong, Yu,Xie, Yixi,Cao, Yi. 2017

[4]Molecular evidence of offspring liver dysfunction after maternal exposure to zinc oxide nanoparticles. Hao, Yanan,Feng, Yanni,Yu, Shuai,Zhang, Weidong,Li, Lan,Min, Lingjiang,Shen, Wei,Zhao, Yong,Liu, Jing,Zhang, Hongfu,Zhao, Yong.

[5]Preparation of Carriers Based on ZnO Nanoparticles Decorated on Graphene Oxide (GO) Nanosheets for Efficient Immobilization of Lipase from Candida rugosa. Zhang, Shan,Shi, Jie,Deng, Qianchun,Zheng, Mingming,Wan, Chuyun,Zheng, Chang,Li, Ya,Huang, Fenghong.

[6]Oocyte exposure to ZnO nanoparticles inhibits early embryonic development through the gamma-H2AX and NF-kappa B signaling pathways. Liu, Jing,Zhao, Yong,Ge, Wei,Zhang, Pengfei,Liu, Xinqi,Zhang, Weidong,Hao, Yanan,Yu, Shuai,Li, Lan,Chu, Meiqiang,Min, Lingjiang,Shen, Wei,Liu, Jing,Zhao, Yong,Zhang, Hongfu. 2017

[7]Simultaneous determination of anabolic steroids and beta-agonists in milk by QuEChERS and ultra high performance liquid chromatography tandem mass spectrometry. Liu, Hongcheng,Lin, Tao,Li, Ning,Wang, Luxiang,Li, Qiwan,Liu, Hongcheng,Lin, Tao,Li, Ning,Wang, Luxiang,Li, Qiwan,Liu, Hongcheng,Lin, Tao,Li, Ning,Wang, Luxiang,Li, Qiwan,Cheng, Xianglei,Li, Ning.

[8]Fabrication and stabilization of biocompatible selenium nanoparticles by carboxylic curdlans with various molecular properties. Yan, Jing-Kun,Qiu, Wen-Yi,Wang, Yao-Yao,Wang, Wen-Han,Yang, Yan,Zhang, He-Nan,Wang, Wen-Han,Yang, Yan,Zhang, He-Nan. 2018

[9]Anti-Phytopathogenic and Cytotoxic Activities of Crude Extracts and Secondary Metabolites of Marine-Derived Fungi. Zhao, Dong-Lin,Wang, Dan,Tian, Xue-Ying,Li, Yi-Qiang,Zhang, Cheng-Sheng,Cao, Fei. 2018

[10]Optimization of Catechin Nanoliposomes and Evaluation of Their Antioxidant Activity and Cytotoxicity. Wu, Zhipan,Guan, Rongfa,Liu, Mingqi,Xiao, Chaogeng,Lyu, Fei,Cao, Guozhou,Gao, Jianguo. 2017

[11]A new drimane sesquiterpenoid glycoside from the seeds of Antiaris toxicaria. Dong, Wen-Hua,Mei, Wen-Li,Zhao, You-Xing,Zeng, Yan-Bo,Wang, Hui,Dai, Hao-Fu,Dong, Wen-Hua,Mei, Wen-Li,Zhao, You-Xing,Zeng, Yan-Bo,Wang, Hui,Dai, Hao-Fu. 2011

[12]Dimeric sesquiterpenoid-4&ITH&IT-chromone derivatives from agarwood of &ITAquilaria crassna&IT and their cytotoxicity. Yang, Yang,Chen, Hui-Qin,Kong, Fan-Dong,Zhou, Li-Man,Li, Wei,Dong, Wen-Hua,Mei, Wen-Li,Dai, Hao-Fu,Yang, Yang,Chen, Zhi-Bao. 2018

[13]Screening of microorganisms from Antarctic surface water and cytotoxicity metabolites from Antarctic microorganisms. Zheng, Lanhong,Yang, Kangli,Sun, Mi,Zhu, Jiancheng,Lv, Mei,Kang, Daole,Wang, Wei,Xing, Mengxin,Li, Zhao,Liu, Jia. 2016

[14]Cytotoxicity and genotoxicity of 1,4-bisdesoxyquinocetone, 3-methylquinoxaline-2-carboxylic acid (MQCA) in human hepatocytes. Zhang, Keyu,Ban, Manman,Zheng, Haihong,Wang, Xiaoyang,Wang, Mi,Fei, Chenzhong,Xue, Feiqun,Zhao, Zhanzhong. 2012

[15]Ustiloxin G, a New Cyclopeptide Mycotoxin from Rice False Smut Balls. Wang, Xiaohan,Wang, Jian,Lai, Daowan,Wang, Weixuan,Zhou, Ligang,Dai, Jungui,Dai, Jungui,Liu, Yang. 2017

[16]Preparation and immunological effectiveness of a Swine influenza DNA vaccine encapsulated in PLGA microspheres. Li, Guo-Xin,Tong, Guang-Zhi,Zhao, Kai,Jin, Yuan-Yuan,Wei, Hai-Xia,Sun, Qing-Shen,Huang, Ting-Ting,Zhao, Kai,Jin, Yuan-Yuan,Wei, Hai-Xia,Huang, Ting-Ting,Wang, Yun-Feng,Tong, Guang-Zhi. 2010

[17]New Xanthone from the Pericarp of Garcinia mangostana. Fu, Manqin,Xu, Yujuan,Wu, Jijun,Chen, Yulong,Yu, Yuanshan,Xiao, Gengsheng,Qiu, Samuel X.. 2013

[18]A new cytotoxic iridoid from Callicarpa nudiflora. Mei, Wen-Li,Han, Zhuang,Cui, Hai-Bin,Deng, Yuan-Yuan,Dai, Hao-Fu,Zhao, You-Xing. 2010

[19]New Azalomycin F Analogs from Mangrove Streptomyces sp 211726 with Activity against Microbes and Cancer Cells. Yuan, Ganjun,Yuan, Ganjun,Hong, Kui,Lin, Haipeng,Yuan, Ganjun,Hong, Kui,She, Zhigang,Li, Jia. 2013

[20]Cytotoxicity and Apoptosis Induction of Bovine Alpha-lactalbumin-oleic Acid Complex in Human Breast Cancer Cells. Zhong, Saiyi,Chen, Suhua,Zhou, Siyi,Qin, Xiaoming,Wang, Weimin,Liu, Shouchun,Liu, Hai.

作者其他论文 更多>>

微信小程序