Angiotensin-I-converting enzyme inhibitory peptides: Chemical feature based pharmacophore generation

文献类型： 外文期刊

第一作者： Wang, Zhanli

作者： Wang, Zhanli;Zhang, Saisai;Feng, Fengqin;Wang, Zhanli;Huo, Jianxin;Zhou, Lishe;Wang, Yongfu;Jin, Hongwei;Zhang, Liangren;Wang, Wei

作者机构：

关键词： Angiotensin-l-converting enzyme;Inhibitory peptide;Pharmacophore modeling;Virtual screening

期刊名称：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY （ 影响因子：6.514； 五年影响因子：6.099 ）

ISSN： 0223-5234

年卷期： 2011 年 46 卷 8 期

页码：

收录情况： SCI

摘要： A validated 3D pharmacophore model was generated for a series of ACE inhibitory peptides, which consisted of five features (two hydrophobic functions, two hydrogen bond acceptors, and a negative ionizable function). The built model was able to correctly predict the activity of known ACE inhibitors. The model was then used as query to search 3D databases of peptides. Three novel peptides (I, II and III) were synthesized and biologically evaluated in vitro. It appears that the in vitro activity of peptides I, II and III was consistent with their molecular modeling results. Our results provided confidence for the utility of the pharmacophore model to retrieve novel ACE inhibitory peptides with desired biological activity by virtual screening. (C) 2011 Elsevier Masson SAS. All rights reserved.

分类号：

  • 相关文献

[1]A Novel Angiotensin I Converting Enzyme Inhibitory Peptide from the Milk Casein: Virtual Screening and Docking Studies. Zhang Sai-sai,Feng Feng-qin,Wang Zhan-li,Shan Wei-guang,Wang Wei. 2011

[2]Exploring the Molecular Basis for Binding of Inhibitors by Threonyl-tRNA Synthetase from Brucella abortus: A Virtual Screening Study. Li, Ming,Wen, Fang,Zhao, Shengguo,Wang, Pengpeng,Li, Songli,Zhang, Yangdong,Zheng, Nan,Wang, Jiaqi,Li, Ming,Wen, Fang,Zhao, Shengguo,Wang, Pengpeng,Li, Songli,Zhang, Yangdong,Zheng, Nan,Wang, Jiaqi,Zheng, Nan,Wang, Jiaqi. 2016

[3]The discovery of new scaffold of plant activators: From salicylic acid to benzotriazole. Chang, Kang,Chen, Jian-Qin,Li, Peng-Fei,Zhu, Wei-Ping,Xu, Yu-Fang,Qian, Xu-Hong,Sun, Mei-Jian,Zhao, Zhen-Jiang,Li, Hong-Lin,Shi, Yan-Xia,Li, Bao-Ju. 2017

[4]Construction of a genome-scale metabolic network of the plant pathogen Pectobacterium carotovorum provides new strategies for bactericide discovery. Wang, Cheng,Chang, Ji-Wei,Kong, De-Xin,Chen, Ling-Ling,Wang, Cheng,Deng, Zhi-Luo,Xie, Zhi-Ming,Chu, Xin-Yi,Chang, Ji-Wei,Kong, De-Xin,Zhang, Hong-Yu,Chen, Ling-Ling,Li, Bao-Ju.

[5]Virtual screening of novel reversible inhibitors for marine alkaline protease MP. Ji, Xiaofeng,Zheng, Yuan,Wang, Wei,Sheng, Jun,Hao, Jianhua,Sun, Mi.

作者其他论文 更多>>

微信小程序