A Novel Angiotensin I Converting Enzyme Inhibitory Peptide from the Milk Casein: Virtual Screening and Docking Studies

文献类型： 外文期刊

第一作者： Zhang Sai-sai

作者： Zhang Sai-sai;Feng Feng-qin;Wang Zhan-li;Shan Wei-guang;Wang Wei

作者机构：

关键词： novel angiotensin I converting enzyme;inhibitory peptide;virtual screening;docking

期刊名称：AGRICULTURAL SCIENCES IN CHINA （ 影响因子：0.82； 五年影响因子：0.997 ）

ISSN： 1671-2927

年卷期： 2011 年 10 卷 3 期

页码：

收录情况： SCI

摘要： Angiotensin I converting enzyme (ACE) plays an important physiological role in the regulation of hypertension. In this study, we applied virtual screening to discover a novel angiotensin I converting enzyme inhibitory peptides from milk casein. One potential hit was identified based on docking scores, subsequently confirmed by activity studies in vitro (IC(50)=20.85 mu mol L(-1)). The proposed peptide in this study contains a unique sequence, Lys-Val-Leu-Ile-Leu-Ala. Moreover, we performed the docking studies to understand the binding mode between the enzyme and peptide hit.

分类号：

  • 相关文献

[1]Angiotensin-I-converting enzyme inhibitory peptides: Chemical feature based pharmacophore generation. Wang, Zhanli,Zhang, Saisai,Feng, Fengqin,Wang, Zhanli,Huo, Jianxin,Zhou, Lishe,Wang, Yongfu,Jin, Hongwei,Zhang, Liangren,Wang, Wei. 2011

[2]Exploring the Molecular Basis for Binding of Inhibitors by Threonyl-tRNA Synthetase from Brucella abortus: A Virtual Screening Study. Li, Ming,Wen, Fang,Zhao, Shengguo,Wang, Pengpeng,Li, Songli,Zhang, Yangdong,Zheng, Nan,Wang, Jiaqi,Li, Ming,Wen, Fang,Zhao, Shengguo,Wang, Pengpeng,Li, Songli,Zhang, Yangdong,Zheng, Nan,Wang, Jiaqi,Zheng, Nan,Wang, Jiaqi. 2016

[3]Binding affinity of five PBPs to Ostrinia sex pheromones. Sun, Yaqi,He, Kanglai,Wang, Zhenying,Sun, Yaqi,Wanner, Kevin W.,Coates, Brad S.. 2017

[4]Exploring stereochemical specificity of phosphotriesterase by MM-PBSA and MM-GBSA calculation and steered molecular dynamics simulation. Zhu, Jingxuan,Li, Xin,Zhang, Siqi,Ye, Hen,Jin, Hanyong,Han, Weiwei,Zhao, Hui. 2017

[5]Mechanisms of imidacloprid resistance in Nilaparvata lugens by molecular modeling. Liu, Gen Yan,Miao, Wei,Ju, Xiu Lian,Liu, Gen Yan,Ju, Xiu Lian. 2010

[6]The discovery of new scaffold of plant activators: From salicylic acid to benzotriazole. Chang, Kang,Chen, Jian-Qin,Li, Peng-Fei,Zhu, Wei-Ping,Xu, Yu-Fang,Qian, Xu-Hong,Sun, Mei-Jian,Zhao, Zhen-Jiang,Li, Hong-Lin,Shi, Yan-Xia,Li, Bao-Ju. 2017

[7]Construction of a genome-scale metabolic network of the plant pathogen Pectobacterium carotovorum provides new strategies for bactericide discovery. Wang, Cheng,Chang, Ji-Wei,Kong, De-Xin,Chen, Ling-Ling,Wang, Cheng,Deng, Zhi-Luo,Xie, Zhi-Ming,Chu, Xin-Yi,Chang, Ji-Wei,Kong, De-Xin,Zhang, Hong-Yu,Chen, Ling-Ling,Li, Bao-Ju.

[8]Virtual screening of novel reversible inhibitors for marine alkaline protease MP. Ji, Xiaofeng,Zheng, Yuan,Wang, Wei,Sheng, Jun,Hao, Jianhua,Sun, Mi.

作者其他论文 更多>>

微信小程序