Human gut microbiome: the second genome of human body

文献类型： 外文期刊

第一作者： Zhu, Baoli

作者： Zhu, Baoli;Wang, Xin;Li, Lanjuan

作者机构：

期刊名称：PROTEIN & CELL （ 影响因子：14.87； 五年影响因子：11.279 ）

ISSN： 1674-800X

年卷期： 2010 年 1 卷 8 期

页码：

收录情况： SCI

摘要： The human body is actually a super-organism that is composed of 10 times more microbial cells than our body cells. Metagenomic study of the human microbiome has demonstrated that there are 3.3 million unique genes in human gut, 150 times more genes than our own genome, and the bacterial diversity analysis showed that about 1000 bacterial species are living in our gut and a majority of them belongs to the divisions of Firmicutes and Bacteriodetes. In addition, most people share a core microbiota that comprises 50-100 bacterial species when the frequency of abundance at phylotype level is not considered, and a core microbiome harboring more than 6000 functional gene groups is present in the majority of human gut surveyed till now. Gut bacteria are not only critical for regulating gut metabolism, but also important for host immune system as revealed by animal studies.

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