Endocytosis, endoplasmic reticulum, actin cytoskeleton affected in tilapia liver under polystyrene microplastics and BDE153 acute co-exposure
文献类型： 外文期刊
第一作者： Zheng, Yao
作者： Zheng, Yao;Li, Jiajia;Zhu, Haojun;Hu, Jiawen;Sun, Yi;Xu, Gangchun
作者机构：
关键词： Liver; Endocytosis; Protein processing in endoplasmic reticulum; Regulation of actin cytoskeleton; Nano-polystyrene microplastics and BDE153 co- exposure
期刊名称：COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY （ 影响因子：4.3； 五年影响因子：4.1 ）
ISSN： 1532-0456
年卷期： 2025 年 289 卷
页码：
收录情况： SCI
摘要： Studies showed that contaminants adhered to the surface of nano-polystyrene microplastics (NPs) have a toxicological effect. Juveniles tilapia were dispersed into four groups: the control group A, 75 nm NPs exposed group B, 5 ng center dot L-1 2,2 ',4,4 ',5,5 '-hexabromodiphenyl ether group C (BDE153), and 5 ng center dot L-1 BDE153 + 75 nm MPs group D, and acutely exposed for 2, 4 and 8 days. The hepatic histopathological change, enzymatic activities, transcriptomics, and proteomics, have been performed in tilapia. The results showed that the enzymatic activities of anti-oxidative (ROS, SOD, EROD), energy (ATP), lipid metabolism (TC, TG, FAS, LPL, ACC), pro-inflammatory (TNF alpha, IL-1 beta) and apoptosis (caspase 3) significantly increased at 2 d in BDE153 and the combined group and together in BDE153 group at 8 d. Histological slice showed displaced nucleus by BDE153 exposure and vacuoles appeared in the combined groups. KEGG results revealed that pathways associated with endocytosis, protein processing in endoplasmic reticulum and regulation of actin cytoskeleton were significantly enriched. The selected genes associated with neurocentral development ( ganab , diaph3/baiap2a/ddost decreased and increased), lipid metabolism ( ldlrap1a decreased, stt3b increased), energy ( agap2 decreased, uggt1 increased) were affected under co-exposure, and fibronectin significantly increased via proteome. Our study indicated that endocytosis, protein processing in endoplasmic reticulum, regulation of actin cytoskeleton were affected in tilapia liver under NPs and BDE153 co-exposure.
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