Nicotinamide-based diamides derivatives as potential cytotoxic agents: synthesis and biological evaluation

文献类型： 外文期刊

第一作者： Peng, Min

作者： Peng, Min;Shi, Liqiao;Ke, Shaoyong

作者机构：

关键词： Nicotinamide;Diamides;Synthesis;Lung cancer;Cytotoxic activity

期刊名称：CHEMISTRY CENTRAL JOURNAL （ 影响因子：4.215； 五年影响因子：3.836 ）

ISSN： 1752-153X

年卷期： 2017 年 11 卷

页码：

收录情况： SCI

摘要： A series of diamides derivatives containing nicotinamide unit were designed, synthesized and evaluated for their potential cytotoxic activities against human cancer cell lines. All the synthesized compounds were characterized using spectroscopic methods mainly including H-1 NMR, C-13 NMR and MS. The bio-evaluation results indicated that some of the obtained compounds (such as 4d, 4h, 4i) exhibited good to moderate cytotoxic effects on lung cancer cell lines (NCI-H460, A549, and NCI-H1975), especially, compound 4d exhibited the highly potential inhibitory activities against NCI-H460 cell line with the IC50 values of 4.07 +/- 1.30 mu g/mL, which might be developed as novel lead compounds for potential cytotoxic agents.

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