A Highly Active CuI/TMEDA Catalytic System for the Coupling Reaction of Acid Chlorides with Terminal Alkynes under Solvent-Free Conditions

文献类型： 外文期刊

第一作者： Yin, Weiyan

作者： Yin, Weiyan;Zhang, Yani;Luo, Di;He, Haifeng;He, Hongwu

作者机构：

关键词： TMEDA;copper(I) iodide;ynones;acid chlorides;terminal alkynes

期刊名称：SYNTHESIS-STUTTGART （ 影响因子：3.157； 五年影响因子：2.743 ）

ISSN： 0039-7881

年卷期： 2014 年 46 卷 19 期

页码：

收录情况： SCI

摘要： A highly efficient copper(I) iodide/N,N,N',N'-tetramethylethylenediamine (CuI/TMEDA) catalytic system for the synthesis of ynones has been developed. A variety of terminal alkynes, including 4-iodophenylacetylene, were smoothly coupled with acid chlorides in the presence 2 mol% CuI and 5 mol% TMEDA to afford the corresponding ynones in good to excellent yields in a short time. It is noteworthy that the reaction is conducted under solvent-free conditions at room temperature.

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