Global effects of subchronic treatment of microcystin-LR on rat splenetic protein levels
文献类型: 外文期刊
第一作者: Li, Guangyu
作者: Li, Guangyu;Qiao, Qin;He, Yan;Zhang, Xuezhen;Yan, Wei;Chen, Jun;Cai, Fei
作者机构:
关键词: Microcystin-LR;Histopathology;Proteomic analysis;Immunotoxicity;Spleen
期刊名称:JOURNAL OF PROTEOMICS ( 影响因子:4.044; 五年影响因子:4.02 )
ISSN: 1874-3919
年卷期: 2012 年 77 卷
页码:
收录情况: SCI
摘要: Microcystin-LR (MCLR), released by toxic cyanobacterial blooms, has received worldwide concerns in the past decades for its hepatotoxicity. Recent studies show that microcystins (MCs) can be accumulated in immune organs and exert notable immunotoxicity. In order to better understand cellular responses in immune tissues disrupted by MCLR treatment, this work mainly focuses on the spleen impairments of rats. After a subchronic 50 d exposure (1 or 10 mu g/kg body weight per day), spleen index, MCLR accumulation, histological change and plasma lysozyme activity were detected in MCLR-treated rat. Results indicated that prolonged exposure of MCLR led to toxin accumulation and caused severe damage in spleen of rats, and eventually impaired the immune functions. To further our understanding of the toxic effects of MCLR on the spleen and the mechanisms behind it, a proteomic analysis was performed to determine the global effects of MCLR on splenetic protein levels. In total, 48 proteins were identified and showed a significant increase or decrease in abundance compared to the control after MCLR exposure. These proteins are mainly involved in immune response, oxidative stress, energetic metabolism and the cytoskeleton assembly, indicating that MCLR exerts complex toxic effects in rat spleen and jointly results in immunotoxicity. (C) 2012 Elsevier B.V. All rights reserved.
分类号:
- 相关文献
作者其他论文 更多>>
-
Physicochemical Characterization and Biological Properties of Polysaccharides from Alpiniae oxyphyllae Fructus
作者:Wang, Risi;Shuai, Xixiang;Wang, Risi;Ruan, Xinmei;Chen, Jun;Deng, Lizhen;Shuai, Xixiang;Liang, Ruihong;Dai, Taotao;Zhou, Wei
关键词:polysaccharides; Alpiniae oxyphyllae fructus; extraction methods; physicochemical properties; antioxidant activities; alpha-amylase inhibition
-
Construction of a high-density genetic map for yardlong bean and identification of ANT1 as a regulator of anthocyanin biosynthesis
作者:Zhang, Hongmei;Zhang, Wei;Liu, Xiaoqing;Chen, Xin;Chen, Huatao;Meng, Shan;Yan, Wei;Hui, Linchong;Chen, Wei
关键词:
-
Residual effects of chlorinated organic pollutants on microbial community and natural redox processes in coastal wetlands
作者:Liu, Meng;Su, Xin;Chen, Yuxuan;Huang, Xiaowei;Yang, Xueling;Zheng, Jinjin;Xu, Jianming;He, Yan;He, Yan;Yuan, Jing;Li, Qinfen
关键词:Chlorinated organic pollutants; Coastal wetland; Community assembly; Facultative organohalide-respiring bacteria; Natural redox processes
-
Comparative Analysis of Chloroplast Pan-Genomes and Transcriptomics Reveals Cold Adaptation in Medicago sativa
作者:Zhang, Tianxiang;Li, Manman;Guo, Changhong;Shu, Yongjun;Chen, Xiuhua;Yan, Wei;Liu, Qian;Li, Yanan;Huang, Wangqi
关键词:alfalfa; chloroplast genome; population structure; genetic variation; cold stress
-
Diversification of wheat-maize double cropping with legume intercrops improves nitrogen-use efficiency: Evidence at crop and cropping system levels
作者:Xia, Haiyong;Li, Xiaojing;Qiao, Yuetong;Xue, Yanhui;Xia, Haiyong;Li, Xiaojing;Qiao, Yuetong;Xia, Haiyong;Yan, Wei;Xue, Yanfang;Cui, Zhenling;Cui, Zhenling;Silva, Joao Vasco;Silva, Joao Vasco;Xia, Haiyong;van der Werf, Wopke
关键词:Simultaneous intercropping; Three-quadrant diagram; Apparent recovery efficiency; EU Nitrogen Expert Panel; Nitrogen surplus
-
Comparative analysis of codon usage patterns in the chloroplast genomes of nine forage legumes
作者:Xiao, Mingkun;Li, Yaqi;Liu, Qian;Shen, Shaobin;Jiang, Tailing;Zhang, Linhui;Zhou, Yingchun;Li, Yuexian;Luo, Xin;Bai, Lina;Yan, Wei;Hu, Xiang
关键词:Forage legume; Codon usage bias; Chloroplast genome; Phylogenetic relationships
-
Nodakenin Ameliorates Ovariectomy-Induced Bone Loss by Regulating Gut Microbiota
作者:Liu, Chunxiao;Wang, Zijiao;Li, Yueyao;Zhang, Yuanyuan;Li, Guangyu;Liu, Chunxiao;Chen, Jingyue
关键词:osteoporosis; nodakenin; gut microbiota; intestinal barrier; metabolomics