Characterization of influenza A virus with nine segments: Effect gene segment on virus property
文献类型: 外文期刊
第一作者: Wu, Rui
作者: Wu, Rui;Shao, Huabin;Luo, Qingping;Yang, Jun;Xu, Diping;Wu, Rui;Shao, Huabin;Xu, Diping;Wu, Rui;Zhang, Xuke
作者机构:
关键词: Influenza virus;H9N2;Nine segments;Virus property
期刊名称:RESEARCH IN VETERINARY SCIENCE ( 影响因子:2.534; 五年影响因子:2.382 )
ISSN: 0034-5288
年卷期: 2012 年 93 卷 2 期
页码:
收录情况: SCI
摘要: The influenza A virus genome consists of eight segments of negative-strand RNA. In previous study, we generated a recombinant influenza virus with nine segments by reverse genetics. In present study, we evaluated characteristics of the recombinant influenza virus. The recombinant virus exhibited similar property to wild-type virus on virion morphology, virion composition, plaque phenotype and other aspects. Whereas, the recombinant virus propagated to lower titers than did wild-type virus in cells and mice, and there was decreased protein level and vRNA incorporation in the recombinant virions compared to wild-type H9N2 virions. Our results indicated that influenza A virus with eight segments exhibits more advantages than the virus with nine segments. (C) 2012 Published by Elsevier Ltd.
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