Koumine Attenuates Lipopolysaccaride-Stimulated Inflammation in RAW264.7 Macrophages, Coincidentally Associated with Inhibition of NF-kappa B, ERK and p38 Pathways

文献类型： 外文期刊

第一作者： Wu, Jing

作者： Wu, Jing;Sun, Zhiliang;Yuan, Zhihang;Wu, Jing;Sun, Zhiliang;Matias, Froilan Bernard;Liang, Zengenni

作者机构：

关键词： inflammation;LPS;NO;koumine;NF-kappa B;RAW264.7 macrophages;iNOS

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.923； 五年影响因子：6.132 ）

ISSN： 1422-0067

年卷期： 2016 年 17 卷 3 期

页码：

收录情况： SCI

摘要： Medicinal herbal plants have been commonly used for intervention of different diseases and health enhancement worldwide. Koumine, an alkaloid monomer found abundantly in Gelsemium plants, can be effectively used as an anti-inflammatory medication. In this study, the mechanisms associated with the preventative effect of koumine on lipopolysaccharide (LPS)-mediated inflammation in RAW264.7 macrophages were investigated. Koumine induced a decrease in the level of inducible nitric oxide synthase (iNOS) protein, concomitant reduction in the production of nitric oxide (NO) and reduction of the levels of interleukin (IL)-6, tumor necrosis factor-alpha (TNF-alpha) and IL-1 beta. Furthermore, koumine decreased the phosphorylation of p65 and inhibited nuclear factor kappa B alpha (I kappa B alpha) proteins, resulting in lower production of nuclear factor (NF)-kappa B transactivation. Koumine also induced a decrease in the phosphorylation of extracellular-signal-regulated kinases (ERK) and p38 in RAW264 cells. In conclusion, these findings reveal that koumine decreases the productions of pro-inflammatory mediators though the suppression of p38 and ERK MAPK phosphorylation and the inhibition of NF-kappa B activation in RAW264.7 cells.

分类号：

  • 相关文献

[1]Chinese herbal medicinal ingredients affect secretion of NO, IL-10, ICAM-1 and IL-2 by endothelial cells. Hu, Yiyi,He, Kongwang,Zhu, Haodan,Hu, Yiyi,He, Kongwang,Zhu, Haodan.

[2]Enhanced Anti-Inflammatory Activities by the Combination of Luteolin and Tangeretin. Funaro, Antonietta,Wu, Xian,Song, Mingyue,Zheng, Jinkai,Guo, Shanshan,Rakariyatham, Kanyasiri,Xiao, Hang,Funaro, Antonietta,Rodriguez-Estrada, Maria Teresa,Xiao, Hang,Zheng, Jinkai,Guo, Shanshan. 2016

[3]INFLAMMATION-RELATED OXIDATIVE STRESS IN WHITE ADIPOSE TISSUES OF AN INBRED OBESE PIG. Yang, X. F.,Jiang, Z. Y.,Tian, Z. M.,Qiu, Y. Q.,Wang, L.,Gao, K. G.,Hu, Y. J.,Ma, X. Y.. 2017

[4]Anti-endotoxin and anti-inflammatory effects of Chinese herbal medicinal alkaloid ingredients in vivo. Hu, Yiyi,Mao, Aihua,Yu, Zhengyu,He, Kongwang,Hu, Yiyi,Mao, Aihua,Yu, Zhengyu,He, Kongwang.

[5]Protective effects of sinomenine against LPS-induced inflammation in piglets. Yang, Haifeng,Jiang, Chunmao,Chen, Xiaolan,He, Kongwang,Hu, Yiyi.

[6]Fibroblast growth factor 21 (FGF21) ameliorates collagen-induced arthritis through modulating oxidative stress and suppressing nuclear factor-kappa B pathway. Yu, Yinhang,Li, Siming,Liu, Yaonan,Tian, Guiyou,Yuan, Qingyan,Bai, Fuliang,Wang, Wenfei,Ren, Guiping,Li, Deshan,Wang, Wenfei,Ren, Guiping,Li, Deshan,Zhang, Yu,Zhang, Zhiyi,Li, Siming. 2015

[7]Infection of Goose with Genotype VIId Newcastle Disease Virus of Goose Origin Elicits Strong Immune Responses at Early Stage. Xu, Qianqian,Chen, Yuqiu,Zhao, Wenjun,Zhang, Tingting,Liu, Chenggang,Qi, Tianming,Ma, Deying,Xu, Qianqian,Chen, Yuqiu,Zhao, Wenjun,Zhang, Tingting,Liu, Chenggang,Qi, Tianming,Han, Zongxi,Shao, Yuhao,Liu, Shengwang. 2016

[8]Nobiletin and its colonic metabolites suppress colitis-associated colon carcinogenesis by down-regulating iNOS, inducing antioxidative enzymes and arresting cell cycle progression. Wu, Xian,Song, Mingyue,Gao, Zili,Sun, Yue,Wang, Minqi,Li, Fang,Zheng, Jinkai,Xiao, Hang,Sun, Yue,Zheng, Jinkai.

[9]Analysis of the immune response in infections of the goldfish (Carassius auratus L.) with Mycobacterium marinum. Hodgkinson, Jordan W.,Ge, Jun-Qing,Grayfer, Leon,Stafford, James,Belosevic, Miodrag,Belosevic, Miodrag,Ge, Jun-Qing.

[10]Isolation of an anti-tumor polysaccharide from Auricularia polytricha (Jew's ear) and its effects on macrophage activation. Qing, Yuan,Yang, Zhirong,Zheng, Linyong,Zheng, Linyong,Yu, Mengyao,Xu, Xiaoyan,Qing, Yuan,Luo, Xia.

[11]In Vitro Antioxidant and Anti-Inflammatory Activities of Protocatechualdehyde Isolated from Phellinus gilvus. Chang, Zhi-Qiang,Gebru, Elias,Rhee, Man-Hee,Park, Seung-Chun,Chang, Zhi-Qiang,Lee, Sam-Pin,Kim, Jong-Choon,Cheng, Henrique. 2011

[12]Nitric oxide promotes light-initiated seed germination by repressing PIF1 expression and stabilizing HFR1. Li, Ruijing,Jia, Yujie,Yang, Wenjuan,Chen, Zhen,Hu, Xiangyang,Yu, Lijuan,Chen, Haiying. 2018

[13]Supplementation of pre-weaning diet with L-arginine has carry-over effect to improve intestinal development in young piglets. Yang, X. F.,Jiang, Z. Y.,Gong, Y. L.,Zheng, C. T.,Hu, Y. J.,Wang, L.,Huang, L.,Ma, X. Y.,Yang, X. F.,Jiang, Z. Y.,Gong, Y. L.,Zheng, C. T.,Hu, Y. J.,Wang, L.,Huang, L.,Ma, X. Y.,Yang, X. F.,Jiang, Z. Y.,Gong, Y. L.,Zheng, C. T.,Hu, Y. J.,Wang, L.,Huang, L.,Ma, X. Y.,Yang, X. F.,Jiang, Z. Y.,Gong, Y. L.,Zheng, C. T.,Hu, Y. J.,Wang, L.,Huang, L.,Ma, X. Y..

[14]The behavior of the manganese-cerium loaded metal-organic framework in elemental mercury and NO removal from flue gas. Zhang, Xiao,Shen, Boxiong,Zhang, Xiaoqi,Si, Meng,Yuan, Peng,Zhang, Xiao,Shen, Feng.

[15]Effects of 1-Methylcyclopropene on NO Content, NOS Activity, and H2O2 Content in Postharvest Suli Pears. Dong Yu,Liu Li-qin,Guan Jun-feng,Dong Yu,Liu Li-qin. 2011

[16]Involvement of NO and ROS in sulfur dioxide induced guard cells apoptosis in Tagetes erecta. Wei, Aili,Zhai, Xiaoyan,Zhang, Xiaobing,Fu, Baocun,Wang, Yunshan,Zhang, Chao,Cao, Dongmei,Xin, Xiaojing.

[17]Dietary soy isoflavone attenuated growth performance and intestinal barrier functions in weaned piglets challenged with lipopolysaccharide. Zhu, Cui,Jiang, Zongyong,Zheng, Chuntian,Wang, Li,Yang, Xuefen,Ma, Xianyong,Gao, Kaiguo,Hu, Youjun,Zhu, Cui,Wu, Yunpeng. 2015

[18]Breed-linked polymorphisms of porcine toll-like receptor 2 (TLR2) and TLR4 and the primary investigation on their relationship with prevention against Mycoplasma pneumoniae and bacterial LPS challenge. Fang, Xiaomin,Liu, Xiao,Meng, Cui,Fu, Yanfeng,Wang, Xuemin,Li, Bixia,Tu, Feng,Zhao, Fang,Ren, Shouwen.

[19]Palmatine inhibits TRIF-dependent NF-kappa B pathway against inflammation induced by LPS in goat endometrial epithelial cells. Yan, Baoqi,Wang, Dongsheng,Dong, Shuwei,Sang, Mengqi,Yang, Zhiqiang,Zhang, Shidong,Yan, Zuoting,Na, Lidong,Yang, Hongzao,Cheng, Zhangrui.

[20]Aqueous extract of Bai-Hu-Tang, a classical Chinese herb formula, prevents excessive immune response and liver injury induced by LPS in rabbits. Zhang, Shidong,Wang, Dongsheng,Wang, Xurong,Yan, Zuoting,Zhang, Shidong,Wang, Dongsheng,Li, Shihong,Li, Jingyu,Zhang, Shidong,Wang, Xurong,Li, Jingyu,Li, Hongsheng,Yan, Zuoting,Zhang, Shidong,Li, Shihong,Li, Hongsheng. 2013

作者其他论文 更多>>

微信小程序