Bidirectional Estrogen-Like Effects of Genistein on Murine Experimental Autoimmune Ovarian Disease
文献类型: 外文期刊
第一作者: Ding, Qiao
作者: Ding, Qiao;Wang, Yuxiao;Li, Na;Hu, Jielun;Nie, Shaoping;Zhu, Kexue;Wang, Sunan;Zhu, Fan
作者机构:
关键词: autoimmune ovarian disease;genistein;zona pellucida;oophoritis;estradiol
期刊名称:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES ( 影响因子:5.923; 五年影响因子:6.132 )
ISSN: 1422-0067
年卷期: 2016 年 17 卷 11 期
页码:
收录情况: SCI
摘要: This study was to investigate the bidirectional estrogen-like effects of genistein on murine experimental autoimmune ovarian disease (AOD). Female BALB/c mice were induced by immunization with a peptide from murine zona pellucida. The changes of estrous cycle, ovarian histomorphology were measured, and the levels of serum sex hormone were analyzed using radioimmunoassay. Proliferative responses of the ovary were also determined by immunohistochemistry. Administration of 25 or 45 mg/kg body weight genistein enhanced ovary development with changes in serum sex hormone levels and proliferative responses. Meanwhile, the proportions of growing and mature follicles increased and the incidence of autoimmune oophoritis decreased, which exhibited normal ovarian morphology in administration of 25 or 45 mg/kg body weight genistein, while a lower dose (5 mg/kg body weight genistein) produced the opposite effect. These findings suggest that genistein exerts bidirectional estrogen-like effects on murine experimental AOD, while a high dose (45 mg/kg body weight) of genistein may suppress AOD.
分类号:
- 相关文献
作者其他论文 更多>>
-
Multifunctional electrospun nanofibrous film integrated with cinnamon essential oil emulsion stabilized by dealkali lignin for active packaging material
作者:Li, Na;Xiang, Hong-jia;Qiu, Wei-peng;Hong, Yu-xuan;Huang, Kai-wen;Wei, Xiao-qun;Wang, Hong;Wen, Peng;Hu, Teng-gen;Guo, Chuang-zong;Yao, Xu-rui
关键词:Cinnamon essential oil; Dealkali lignin; Emulsion electrospinning; Antibacterial; Antioxidant
-
Biodegradable taro stem cellulose aerogel: A simple approach for adsorbing microplastics and dyestuffs contaminants
作者:Qiu, Wei-peng;Su, Hai-ze;Su, Hao;Li, Na;Lai, Li-shan;Zhu, Jia-le;Xu, Zhen-lin;Wang, Hong;Wen, Peng;Hu, Teng-gen;Zhao, Ya-li;Wen, Peng
关键词:Biomass aerogel; Taro stem microcrystalline cellulose; Microplastics and dyes; Adsorption mechanism
-
Mechanism of fatty acid synthesis metabolism during tuber swelling period of Chinese yam
作者:Li, Na;Zhang, Yanfang;Huo, Xiuwen;Suo, Ningning;Tang, Ye;Guo, Shuchun
关键词:Yam; GC-MS; Fatty acid anabolism; Dioscores; Low-temperature tolerance
-
Inversion of nitrogen and phosphorus contents in cotton leaves based on the Gaussian mixture model and differences in hyperspectral features of UAV
作者:Peng, Lei;Xin, Hui-Nan;Lv, Cai-Xia;Li, Na;Li, Yong-Fu;Geng, Qing-Long;Chen, Shu-Huang;Lai, Ning
关键词:Gaussian mixture modeling; Spectral difference classification; Field trials; Machine learning
-
A Novel Land Surface Temperature Retrieval Algorithm for SDGSAT-1 Images
作者:Li, Na;Wang, Yunpeng;Li, Na;Wang, Yunpeng;Li, Na;Xu, Jianhui;Li, Xu;Zhong, Kaiwen;Qin, Zhihao;Qin, Boxiong;Qin, Boxiong;Fu, Dongjie;Fu, Dongjie;Qin, Zhihao
关键词:Land surface temperature; Spatial resolution; Land surface; Grasslands; Sensors; Remote sensing; MODIS; Atmospheric measurements; Landsat; Vegetation mapping; Land surface temperature (LST); retrieval algorithms; Sustainable Development Goals Science Satellite 1 (SDGSAT-1); validation
-
Synergistic effect of pectin and the flavanols mixture on in vitro starch digestion and the corresponding mechanism
作者:Qin, Yajuan;Zhang, Yutong;Chen, Xiaoai;Xu, Fei;Zhu, Kexue;Zhang, Yanjun;Qin, Yajuan;Qin, Yajuan;Wang, Ping;Qin, Yajuan;Zhang, Yutong;Chen, Xiaoai;Xu, Fei;Zhu, Kexue;Zhang, Yanjun;Qin, Yajuan;Zhang, Yutong;Chen, Xiaoai;Xu, Fei;Zhu, Kexue;Zhang, Yanjun;Zhang, Yutong
关键词:Rutin; Quercetin; Kaempferol; alpha-Glucosidase; Pectin; In vitro starch digestion
-
Comparison of phenolic profiles and antioxidant activities in the pulps from 21 different Artocarpus heterophyllus Lam. cultivars
作者:Cheng, Ming;Liu, Mengyang;Tan, Lehe;Wu, Gang;Xu, Bingqiang;Zhang, Yanjun;Zhu, Kexue;Cheng, Ming;Liu, Mengyang;Tan, Lehe;Wu, Gang;Xu, Bingqiang;Zhang, Yanjun;Zhu, Kexue;Cheng, Ming;Li, Chuan;Cheng, Ming;Xu, Bingqiang;Liu, Mengyang;Wu, Gang;Zhang, Yanjun;Zhu, Kexue;Liu, Mengyang;Zhang, Yanjun;Zhu, Kexue
关键词:Artocarpus heterophyllus Lam.; Phenolic profile; Antioxidant activity; UPLC-ESI-Q-TOF-MS/MS