Coassembled nanostructured bioscaffold reduces the expression of proinflammatory cytokines to induce apoptosis in epithelial cancer cells

文献类型： 外文期刊

第一作者： Li, Rui

作者： Li, Rui;Pavuluri, Sivapriya;Long, Benjamin M.;Pfeffer, Frederick M.;Nicholas, Kevin R.;Barrow, Colin J.;Williams, Richard J.;Bruggeman, Kiara;Nisbet, David R.;Parnell, Andrew J.;Martel, Anne;Dennison, Andrew J. C.;Parnell, Steven R.;Li, Rui;Pavuluri, Sivapriya;Nicholas, Kevin R.;Williams, Richard J.;Williams, Richard J.;Dennison, Andrew J. C.

作者机构：

关键词： Bionanotechnology;Self-assembly;Cancer;Supramolecular materials;Hydrogels;Tissue engineering

期刊名称：NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE （ 影响因子：6.458； 五年影响因子：7.072 ）

ISSN： 1549-9634

年卷期： 2016 年 12 卷 5 期

页码：

收录情况： SCI

摘要： The local inflammatory environment of the cell promotes the growth of epithelial cancers. Therefore, controlling inflammation locally using a material in a sustained, non-steroidal fashion can effectively kill malignant cells without significant damage to surrounding healthy cells. A promising class of materials for such applications is the nanostructured scaffolds formed by epitope presenting minimalist self-assembled peptides; these are bioactive on a cellular length scale, while presenting as an easily handled hydrogel. Here, we show that the assembly process can distribute an anti- inflammatory polysaccharide, fucoidan, localized to the nanofibers within the scaffold to create a biomaterial for cancer therapy. We show that it supports healthy cells, while inducing apoptosis in cancerous epithelial cells, as demonstrated by the significant down-regulation of gene and protein expression pathways associated with epithelial cancer progression. Our findings highlight an innovative material approach with potential applications in local epithelial cancer immunotherapy and drug delivery. (C) 2016 Elsevier Inc. All rights reserved.

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