1,4,6-trihydroxy-8-alkylated-9,10-anthraquinones with antibacterial activities from soil-derived Streptomyces sp. WS-13394

文献类型： 外文期刊

第一作者： Wu, Zhaoyuan

作者： Wu, Zhaoyuan;Liu, Manli;Li, Kui;Liu, Fang;Zhang, Fei;Zhang, Yani;Wang, Kaimei;Fang, Wei

作者机构：

期刊名称：JOURNAL OF ANTIBIOTICS （ 影响因子：3.424； 五年影响因子：3.066 ）

ISSN： 0021-8820

年卷期： 2022 年 75 卷 7 期

页码：

收录情况： SCI

摘要： Two new 1,4,6-trihydroxy-8-alkylated-9,10-anthraquinones (1-2) were isolated from the culture broth of the soil actinomycete Streptomyces sp. WS-13394. Their structures were elucidated on the basis of extensive spectroscopic analysis, including mass spectrometry (MS), nuclear magnetic resonance (NMR), and electronic circular dichroism (ECD). Compounds 1 and 2, together with eight analogs (3-10), were evaluated for their antibacterial activities against five pathogens. The tested derivatives of alkylated anthraquinone exhibited selective activities to Gram-positive bacteria, while compounds 1 and 5 showed obvious activities against two zoonotic pathogens, Erysipelothrix rhusiopathiae and Streptococcus suis, with MIC values ranging from 3.13 to 12.5 mu g ml(-1).

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