Microencapsulation of coupled folate and chitosan nanoparticles for targeted delivery of combination drugs to colon

文献类型: 外文期刊

第一作者: Li, Puwang

作者: Li, Puwang;Yang, Ziming;Peng, Zheng;Li, Sidong;Kong, Lingxue;Wang, Qinghuang;Wang, Yichao;Kong, Lingxue;Wang, Qinghuang

作者机构:

关键词: 5-Fluorourical;colon cancer;drug delivery;leucovorin;microencapsulation

期刊名称:JOURNAL OF MICROENCAPSULATION ( 影响因子:3.142; 五年影响因子:2.933 )

ISSN: 0265-2048

年卷期: 2015 年 32 卷 1 期

页码:

收录情况: SCI

摘要: Folate-chitosan nanoparticles, co-loaded with 5-fluourouacil (5-FU) and leucovorin (LV) and prepared by ionic gelation technology were physically microencapsulated by enteric polymer using a solvent evaporation method. Average particle size of the microencapsulated particles was in the range of 15 to 35 mm. High drug encapsulation efficiency was obtained for both 5-FU and LV in the microencapsulated particles. Both drugs were in amorphous state in the microencapsulated particles. By enteric coating, excellent pH-dependent release profile was achieved and no drug release was observed in simulated gastric and intestinal fluids. However, when the pH value reached the soluble threshold of Eudragit S-100, a constant and slow drug release was observed. The results indicated that these microencapsulated particles are a promising vehicle for selectively targeting drugs to colon in the chemotherapy of colon cancer.

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