Storage stability and skin permeation of vitamin C liposomes improved by pectin coating

文献类型： 外文期刊

第一作者： Zhou, Wei

作者： Zhou, Wei;Liu, Wei;Zou, Liqiang;Liu, Weilin;Liu, Chengmei;Liang, Ruihong;Chen, Jun;Zhou, Wei

作者机构：

关键词： Liposomes;Pectin;Vitamin C;Storage stability;Skin permeation

期刊名称：COLLOIDS AND SURFACES B-BIOINTERFACES （ 影响因子：5.268； 五年影响因子：4.957 ）

ISSN： 0927-7765

年卷期： 2014 年 117 卷

页码：

收录情况： SCI

摘要： A transdermal drug delivery system was prepared by high methoxyl pectin (HMP) or low methoxyl pectin (LMP) coated vitamin C liposomes. HMP coated vitamin C liposomes (HMP-L) and LMP coated vitamin C liposomes (LMP-L) exhibited an increase in average diameter (from 66.9 nm to 117.3 nm and 129.6 nm, respectively), a decrease in zeta potential (from -2.3 mV to -23.9 mV and -35.5 mV, respectively), and a similar entrapment efficiency (48.3-50.1%). Morphology and FIR analysis confirmed that pectin was successfully coated on the surface of vitamin C liposomes mainly through the hydrogen bonding interactions. Besides, HMP-L and LMP-L exhibited an obvious improvement in storage stability, with lower aggregation, oxidation of lipid and leakage ratio of vitamin C from liposomes, and LMP-L showed better physicochemical stability than HMP-L. Moreover, skin permeation of vitamin C was improved 1.7-fold for HMP-L and 2.1-fold for LMP-L after 24h, respectively, compared with vitamin C nanoliposomes. Therefore, this study suggested that pectin coated liposomes, especially the LMP-L, could be a promising transdermal drug delivery system with better storage stability and skin permeation. (C) 2014 Elsevier B.V. All rights reserved.

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