F-01A, an antibiotic, inhibits lung cancer cells proliferation

文献类型： 外文期刊

第一作者： Wang Jing

作者： Wang Jing;Song Xin-Ming;Han Chang-Ri;Chen Guang-Ying;Wang Jing;Chen Zhong;Wu Xiao-Peng

作者机构：

关键词： Apoptosis;Membrane potential;SPC-A-1 cells;Polyether antibiotic

期刊名称：CHINESE JOURNAL OF NATURAL MEDICINES （ 影响因子：3.0； 五年影响因子：2.869 ）

ISSN： 2095-6975

年卷期： 2014 年 12 卷 4 期

页码：

收录情况： SCI

摘要： AIM: In an effort to identify novel, small molecules which can affect the proliferation of lung cancer cells, F-01A, a polyether antibiotic isolated from the fermentation broth of Streptomyces was tested. METHOD: F-01A was tested for its antitumor properties on the lung cancer cell line SPC-A-1, at six doses (0.1, 0.5, 1, 2.5, and 5 mu mol.L-1), using various cellular assays. Cell viability was measured by the MTT assay, Hochest 33258 was used to study nuclear morphology; DNA ladder and the loss of mitochondrial membrane potential were also evaluated. RESULTS: F-01A induces apoptosis against SPC-A-1 cells in a dose-dependent manner. The IC50 is 0.65 mu mol.L-1, and the inhibition at 5 mu mol.L-1 is 87.89%. Further, JC-1 staining indicates F-01A could induce the loss of mitochondrial membrane potential, and the DNA fragment is evident. CONCLUSION: Mechanistic analysis showed that F-01A induced apoptosis of cancer cells probably in the mitochondrial pathway. The antitumor actions of F-01A involve activation of the apoptotic pathway against SPC-A-1 cells, and it may be valuable for further drug development.

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