Chitosan-Modified PLGA Nanoparticles with Versatile Surface for Improved Drug Delivery

文献类型： 外文期刊

第一作者： Wang, Yichao

作者： Wang, Yichao;Li, Puwang;Kong, Lingxue;Li, Puwang

作者机构：

关键词： chitosan;drug delivery system;nanoparticles;PLGA;versatility

期刊名称：AAPS PHARMSCITECH （ 影响因子：3.246； 五年影响因子：3.473 ）

ISSN： 1530-9932

年卷期： 2013 年 14 卷 2 期

页码：

收录情况： SCI

摘要： Shortage of functional groups on surface of poly(lactide-co-glycolide) (PLGA)-based drug delivery carriers always hampers its wide applications such as passive targeting and conjugation with targeting molecules. In this research, PLGA nanoparticles were modified with chitosan through physical adsorption and chemical binding methods. The surface charges were regulated by altering pH value in chitosan solutions. After the introduction of chitosan, zeta potential of the PLGA nanoparticle surface changed from negative charge to positive one, making the drug carriers more affinity to cancer cells. Functional groups were compared between PLGA nanoparticles and chitosan-modified PLGA nanoparticles. Amine groups were exhibited on PLGA nanoparticle surface after the chitosan modification as confirmed by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. The modified nanoparticles showed an initial burst release followed by a moderate and sustained release profile. Higher percentage of drugs from cumulative release can be achieved in the same prolonged time range. Therefore, PLGA nanoparticles modified by chitosan showed versatility of surface and a possible improvement in the efficacy of current PLGA-based drug delivery system.

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