Mathematical Derivation of Concentration Addition, Independent Action and Effect Summation Models

文献类型： 外文期刊

第一作者： Ge Hui-Lin

作者： Ge Hui-Lin;Su Bing-Xia;Xu Zhi;Ge Hui-Lin;Liu Shu-Shen

作者机构：

关键词： mixture toxicity;concentration addition;independent action;effect summation

期刊名称：SUSTAINABLE CITIES DEVELOPMENT AND ENVIRONMENT PROTECTION, PTS 1-3

ISSN： 1660-9336

年卷期： 2013 年 361-363 卷

页码：

收录情况： SCI

摘要： The assessment of the combined effects of substances is usually based on concentration addition (CA), independent action (IA) or effect summation (ES) models. Both concepts are founded on different modes of actions of substances, but the knowledge about their relationship is rare. In this paper, we derived a series of inequalities for CA, IA and ES models, and proposed two novel models i.e., ES with the exponent e (ESE) model and ES with the power of the number of components n (ESN) model to evaluate the mixture effect. Our results may have certain significance in mixture risk assessment practices.

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