Preparation of nanoparticles by crosslinking folate conjugated chitosan with vanillin and its characterization

文献类型： 外文期刊

第一作者： Zhou, Min

作者： Zhou, Min;Li, Puwang;Wang, Guang;Yang, Ziming;Peng, Zheng;Kong, Lingxue

作者机构：

关键词： Folic acid;chitosan;vanillin;chemical modification

期刊名称：INTELLIGENT SYSTEM AND APPLIED MATERIAL, PTS 1 AND 2

ISSN： 1022-6680

年卷期： 2012 年 466-467 卷

页码：

收录情况： SCI

摘要： Functionalized chitosan (CS) were widely used as drug delivery system in the chemotherapy of various disease. In this work, folate (FA) was conjugated into chitosan molecular as targeting ligand based on Schiff reaction between -NH2 group of CS and -COOH group of FA. And nanoparticles were made by emulsion method with vanillin novel cross-linking agent. The FA modified CS and its nanoparticles were characterized by Fourier transform spectroscopy (FT-IR), scanning electron microscope (SEM) and Zeta potential. SEM results confirmed the nanoparticles made from FA-CS conjugate were spherical in shape and were about 100 nm in size. Zeta potential analysis revealed that the nanoparticles were negatively charged with charge density of -7.73mV.

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