Design, semisynthesis and insecticidal activity of novel podophyllotoxin derivatives against Brontispa longissima in vivo

文献类型: 外文期刊

第一作者: Liu, Ying-Qian

作者: Liu, Ying-Qian;Zhao, Yong-Long;Zhou, Xing-Wen;Yang, Liu;Feng, Gang

作者机构:

关键词: Podophyllotoxin;Antifeedant activity;Insecticidal activity;X-ray diffraction;Docking analysis;Tubulin inhibitory effect

期刊名称:PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY ( 影响因子:3.963; 五年影响因子:4.454 )

ISSN: 0048-3575

年卷期: 2012 年 102 卷 1 期

页码:

收录情况: SCI

摘要: In an attempt to find the effective phytopesticides, a series of novel podophyllotoxin derivatives were firstly synthesized and preliminarily tested for their antifeedant and insecticidal effects against the fifth-instar larvae of Brontispa longissima. The different antifeedant and insecticidal activity ranges of compounds 3a-1 showed that variations of NR(1)R(2) groups in the 4-position of podophyllotoxin skeleton markedly affected the activity profiles of this compound class, and some important SAR information has been revealed from it. To clarify their mode of action of insecticidal activity, the clocking models as well as tubulin inhibitory effect of representative compound 3i were also investigated, and the result indicated that the insecticidal activity of these compounds was due to the tubulin inhibitory effect of these derivatives, thereby possibly providing some useful information for rational designs of novel podophyllotoxin-based insecticides. (C) 2011 Elsevier Inc. All rights reserved.

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