Cytotoxic and Antibacterial Flavonoids from Dragon's Blood of Dracaena cambodiana

文献类型： 外文期刊

第一作者： Luo, Ying

作者： Luo, Ying;Wang, Hui;Zhao, You-Xing;Zeng, Yan-Bo;Shen, Hai-Yan;Dai, Hao-Fu;Mei, Wen-Li;Wang, Hui;Zhao, You-Xing;Zeng, Yan-Bo;Dai, Hao-Fu;Mei, Wen-Li

作者机构：

关键词： Dracaena cambodiana;Agavaceae;dragon's blood;flavonoids;cytotoxicity;antibacterial activity

期刊名称：PLANTA MEDICA （ 影响因子：3.352； 五年影响因子：3.4 ）

ISSN： 0032-0943

年卷期： 2011 年 77 卷 18 期

页码：

收录情况： SCI

摘要： Chemical studies on the constituents from the dragon's blood of Dracaena cambodiana led to the discovery of three new flavonoid derivatives (1-3) and six known compounds (4-9). The structures of the three new compounds were elucidated by NMR and MS spectroscopic analyses. All compounds were evaluated for their growth inhibitory activity against human cell lines K-562, SMMC-7721, and SGC-7901, as well as antibacterial activities against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA). As a result, compounds 1, 2, 5, 7, and 9 showed cytotoxicity against K-562, SMMC-7721, and SGC-7901 cell lines. All these compounds were observed to exhibit antibacterial activities against S. aureus, and compounds 1-4, 6, 8, and 9 were observed to exhibit antibacterial activity against MRSA.

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