Podophyllotoxin-derived insecticidal agents: Part XIII - Evaluation of insecticidal activity of podophyllotoxin derivatives against Brontispa longissima

文献类型： 外文期刊

第一作者： Liu, Ying-Qian

作者： Liu, Ying-Qian;Li, Hong-Yu;Liu, Ying-Qian;Li, Hong-Yu;Feng, Gang;Jing-Zhang;Yang, Liu

作者机构：

关键词： podophyllotoxin;insecticidal activity;Brontispa longissima;structure-activity relationships

期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.861； 五年影响因子：2.572 ）

ISSN： 1478-6419

年卷期： 2011 年 25 卷 16 期

页码：

收录情况： SCI

摘要： In an attempt to find the biorational insecticides for Brontispa longissima control, 12 podophyllotoxin (PPT) analogues were tested for their insecticidal activity against the fifth-instar larvae of B. longissima in vivo for the first time. Among all the tested compounds, especially compounds 6 and 8 showed more promising and pronounced insecticidal activity than toosendanin, a commercial insecticide derived from Melia azedarach. The different insecticidal activity range of compounds 1-12 indicated that the variation of chemical structures in the PPT skeleton markedly affected the activity profiles of this compound class, and some important structure-activity relationship information has been revealed. Together, these preliminary results may be useful in guiding further modification of PPTs in the development of potential new insecticides.

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