文献类型： 外文期刊
第一作者： Quan, Xiao Fang
作者： Quan, Xiao Fang;Tian, Wei Xi;Ma, Xiao Feng;Jiang, He Zhong;Hu, Jiang Miao;Wang, Peng Cheng;Huang, Sheng Zhuo;Cheng, Zhong Quan;Liang, Wen Juan;Zhou, Jun;Zhao, You Xing;Zhao, You Xing
作者机构：
关键词： Fatty acid synthase (FAS);Garcinia mangostana;Xanthone;Benzophenone;FAS inhibitors
期刊名称：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS （ 影响因子：2.823； 五年影响因子：2.677 ）
ISSN： 0960-894X
年卷期： 2010 年 20 卷 20 期
页码：
收录情况： SCI
摘要： Natural inhibitors of fatty acid synthase (FAS) are emerging as potential therapeutic agents to treat cancer and obesity. The bioassay-guided chemical investigation of the hulls of Garcinia mangostana led to the isolation of 13 phenolic compounds (1-13) mainly including xanthone and benzophenone, in which compounds 7, 8, 9, 10, and 11 were isolated from this plant for the first time and compound 9 was a new natural product. These isolates possess strong inhibitory activity of FAS with the IC(50) values ranging from 1.24 to 91.07 mu M. The study indicates that two types of natural products, xanthones and benzophenones, could be considered as promising FAS inhibitors. (c) 2010 Elsevier Ltd. All rights reserved.
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