The Prophet of PIT1 Gene Variation and its Effect on Growth Traits in Chinese Indigeous Goat

文献类型： 外文期刊

第一作者： Xu, T. S.

作者： Xu, T. S.;Zhou, H. L.;Liu, J. B.;Yao, D. W.;Cai, H. F.;Chen, H.;Lan, X. Y.

作者机构：

关键词： Goat;Prophet of PIT1 (PROP1) gene;Single Nucleotide Polymorphism (SNP);PCR-RFLP;Marker Assisted Selection (MAS);genotype

期刊名称：JOURNAL OF ANIMAL AND VETERINARY ADVANCES （ 影响因子：0.365； 五年影响因子：0.359 ）

ISSN： 1680-5593

年卷期： 2010 年 9 卷 23 期

页码：

收录情况： SCI

摘要： Due to the significant influence of GET, PRL and PIT1 mutations on production traits, Prophet of PIT1 (PROP 1) regulating them is considered as an important and potential candidate gene for goat growth traits by Marker Assisted Selection (MAS). Using Hin6I PCR-RFLP, this study verified the AF453512: g.1795C > T resulting in GCG (79Ala)>GTA (79Val) within PROP1 gene in Hainan Black Goat (HNBG). Three genotypes (CC, CT and TT) were observed and their frequencies were 0.310, 0.493 and 0.197, respectively. The allelic frequencies of allele C and T were 0.556 and 0.444, respectively in analyzed population with Hardy-weinberg equilibrium (p>0.05). Combining with the reported genotypic frequencies at Hin6I locus in cashmere goat breeds (IMWC and SBWC), dairy goat breeds (Sa, LS and GZ), genotypic frequency of HNBG population showed significant differences when compared with other goat breeds (p<0.001) as well as significant differences of allelic frequencies between HNBG and other breeds were revealed (p<0.001), implying that the allele T possibly was associated with the meat traits and growth traits. Association analysis showed significant relationships between Hin6I polymorphisms and Body Length (BL), Chest Circumferene (ChC), Chest Width (ChW) and Cannon Circumference Index (CaCI) ((p<0.05), suggesting that the PROP1 gene produced significant influences on growth trait. The individuals with genotype CT demonstrated better Body Length (BL), Chest Circumferene (ChC) and Cannon Circumference Index (CaCI) (p<0.05) when compared with those of individuals with genotype CC.

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