文献类型： 外文期刊

第一作者： Dai, HF

作者： Dai, HF;Edrada, RA;Ebel, R;Nimtz, M;Wray, V;Proksch, P

作者机构：

期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：4.05； 五年影响因子：4.603 ）

ISSN： 0163-3864

年卷期： 2005 年 68 卷 8 期

页码：

收录情况： SCI

摘要： Along with five known 30-norlanostane-type saponins, sarasinosides A(1) (5A), A(3) (6A), h (7), 12 (8), and H-2 (9), four new triterpenoidal saponin congeners, sarasinosides J (1), K (2), L (3), and M (4), were isolated from the Indonesian sponge Melophlus sarassinorum. Sarasinosides J (1) and K (2) are the 24,25-hydrogenated congeners of the previously described sarasinosides A(1) and H-2, respectively. The carbon skeleton of sarasinoside M (4) possesses a rearranged 8 alpha,9 alpha-epoxy-8,9-seconorlanosta-8(14),9(11),24-triene system, which is novel and unprecedented in nature. The structures of the new compounds were confirmed by spectral analyses, chemical derivatization, and GC analyses. Compounds 1 and 5A exhibited antimicrobial activity toward Bacillus subtilis and Saccharomyces cerevisiae.

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