Acute Toxicity of Seleniferous Pleurotus Geesteranus Mycelia and Antioxidation against D-galactose-induced Mice

文献类型： 外文期刊

第一作者： Chen, Jun-chen

作者： Chen, Jun-chen;Wu, Li;Shen, Heng-sheng;Weng, Min-jie;Lai, Pu-fu

作者机构：

关键词： Seleniferous mushroom;Pleurotus geesteranus singer;Antioxidant;Acute toxicity;Mouse

期刊名称：PROCEEDINGS OF THE 2016 INTERNATIONAL CONFERENCE ON BIOMEDICAL AND BIOLOGICAL ENGINEERING

ISSN：

年卷期： 2016 年

页码：

收录情况： SCI

摘要： Liquid culture of seleniferous mycelia of Pleurotus geesteranus Singer (SeMyc-P) was evaluated for its acute toxicity in supplement application and antioxidant against D-galactose induced oxidation damaged mice. Maximum Tolerant Dose (MTD) of SeMyc-P was about 20g/kg bw for mice to define safety application for selenium supplement against acute toxicity. Comparing with carboxymethyl cellulose sodium (CMC) control and VitE standard group, SeMyc-P in 10-days administration increased blood GSH-Px about 24.8-52.0% and 17.1-42.6%, respectivily. By 45-days administration against D-galactose induced oxidative stress mice, the optimal given level of SeMyc-P was 0.2 mu g/hd/d equivalent to 5-times of DRIs in selenium for Recommended Nutritional Intake (RNI=50 mu g/d), which increased blood GSH-Px 18.48% than CK-m group concomitant with decreasing MDA and protein carbonyl for 22.19% and 44.16%, respectively.

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