Analysis on the Genetic Variation of KAP3.1 and KAP6.1 Gene in 6 Rabbit Populations

文献类型： 外文期刊

第一作者： Wu Tian-Wen

作者： Wu Tian-Wen;Mao-Liu-Liu;Li Bi-Chun;Wu Xin-Sheng;Li-Tang;Feng-Kai

作者机构：

关键词： Rabbit;KAP3.1 gene;KAP6.1 gene;genetic variation;Hardy-Weinberg equilibrium;China

期刊名称：JOURNAL OF ANIMAL AND VETERINARY ADVANCES （ 影响因子：0.365； 五年影响因子：0.359 ）

ISSN： 1680-5593

年卷期： 2011 年 10 卷 7 期

页码：

收录情况： SCI

摘要： Researchers had scanned the complete CDS of rabbit KAP3.1 and KAP6.1 gene for the 1st time by PCR-SSCP and detected that their homology with mouse, chimpanzee, human, sheep and goat were >80%, suggesting that the two genes among different species kept high conservation in evolution. In this study, three genotypes and two alleles were found at KAP3.1-1 locus having one silent mutation (C91T) and there were two alleles and three genotypes in 5 un-translated region of KAP6.1 gene with the A 755 G mutation of the enhancer region. Herein, the distribution of these genotypes in all populations was consistent with the Hardy-Weinberg equilibrium and showed intermediate or low diversity. The result suggested a theoretical reference to the breeding of rabbit wool quality whether KAP3.1 and KAP6.1 gene could be a molecular marker or not.

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