Metabolomics reveals changes in metabolite concentrations and correlations during sexual development of Eurotium cristatum (synonym: Aspergillus cristatus)

文献类型： 外文期刊

第一作者： Ren, C. G.

作者： Ren, C. G.;Ren, C. G.;Ren, C. G.;Tan, Y. M.;Liu, Y. X.;Tan, Y. M.;Liu, Y. X.;Liu, Z. Y.;Ren, X. X.

作者机构：

关键词： Eurotium cristatum;Fungus;Metabolite;metabolite correlation;Metabolomic

期刊名称：MYCOSPHERE （ 影响因子：4.211； 五年影响因子：2.866 ）

ISSN： 2077-7000

年卷期： 2017 年 8 卷 10 期

页码：

收录情况： SCI

摘要： Eurotium cristatum is the main probiotic fungus involved in fermentation of Chinese Fuzhuan brick tea, and the amount of E. cristatum is an important indicator of tea quality. Sexual development of E. cristatum consists of three main stages, hypha and ascogonium (at 36 hours post-inoculation), cleistothecium formation (at 48 hours), and cleistothecium ripening (at 72 hours), and each stage exhibits a unique metabolite profile. In this study, developmental changes were analyzed by GC-MS based untargeted metabolomics. Ninety-nine metabolites involved in multiple biochemical pathways were identified. Principal component analysis separated developing E. cristatum into 36, 48 and 72 hour groups. Hierarchical cluster analyses showed that the relative contents of organic acids and amino acids peaked at 36 hours and decreased thereafter, while alcohol and carbohydrate levels peaked at 48-72 hours. Statistical analysis revealed 401 significant metabolite-metabolite correlations (Pearson's vertical bar r vertical bar>0.8 at a false discovery rate <= 0.05), of which 213 were positive and 188 negative. The early increases in organic acid and amino acid metabolites as well as certain phosphate and amine metabolites favor ascogonium formation. Conversely, increased alcohol and carbohydrate concentrations favor cleistothecium formation. These results provide a foundation for further exploration of the biochemical mechanism underlying sexual development in E. cristatum.

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