Effects of Acanthopanax senticosus Polysaccharide Supplementation on Growth Performance, Immunity, Blood Parameters and Expression of Pro-inflammatory Cytokines Genes in Challenged Weaned Piglets

文献类型： 外文期刊

第一作者： Han, Jie

作者： Han, Jie;Bian, Lianquan;Liu, Xianjun;Zhang, Fei;Zhang, Yiran;Yu, Ning

作者机构：

关键词： Herbal Extract;Stress;Growth;Cytokines;Metabolism;Weaned Pigs

期刊名称：ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES （ 影响因子：2.509； 五年影响因子：2.604 ）

ISSN： 1011-2367

年卷期： 2014 年 27 卷 7 期

页码：

收录情况： SCI

摘要： To investigate the effect of dietary Acanthopanax senticosus polysaccharide (ASPS) on growth performance, immunity, blood parameters and mRNA expression of pro-inflammatory cytokines in immunologically challenged piglets, an experiment employing 2x2 factorial arrangement concerning dietary ASPS treatment (0 or 800 mg/kg) and immunological challenge (lipopolysaccharide [LPS] or saline injection) was conducted with 64 crossbred piglets (weaned at 28 d of age, average initial body weight of 7.25 +/- 0.21 kg) assigned to two dietary ASPS treatments with 8 replicates of 4 pigs each. Half of the piglets of per dietary treatment were injected with LPS or saline on d 14. Blood samples were obtained at 3 h after immunological injection on d 14 and piglets were slaughtered to obtain spleen samples on d 21. Dietary ASPS did not affect average daily gain (ADG) (p = 0.634), average daily feed intake (ADFI) (p = 0.655), and gain:feed (p = 0.814) prior to LPS challenge. After LPS challenge, for LPS-challenged pigs those fed ASPS had higher ADG and ADFI than the non-supplemented group (p<0.05), and an interaction between LPSxASPS was observed on the two indices (p<0.05). Dietary ASPS improved lymphocyte proliferation among saline-injected and LPS-injected pigs (p<0.05). Interaction between LPSxASPS was also revealed on lymphocyte proliferation (p<0.05). Circulatory concentration of IgG was influenced neither by ASPS (p = 0.803) or LPS (p = 0.692), nor their interaction (p = 0.289). Plasma concentration and spleen mRNA expression of interleukin-1beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor (TNF)-alpha were induced to increase (p<0.05) by LPS challenge, in contrast, these indices were decreased by dietary ASPS (p<0.05), and interactions were found on these cytokines (p<0.05). For LPS-challenged pigs, dietary ASPS also reduced the circulating concentration and spleen mRNA expression of IL-1 beta, IL-6 as well as TNF-alpha (p<0.05). The interaction between LPSxASPS was also observed on the circulating concentration of insulin-like growth factor- I, alpha-acid glycoprotein (alpha-AGP), nonesterified fatty acid, and glucose (p<0.05). The results of this study demonstrate that dietary ASPS can modulate the release of pro-inflammatory cytokines during immunological challenge, which might enable piglets to achieve better growth performance.

分类号：

  • 相关文献

[1]Iron nutrition affects cadmium accumulation and toxicity in rice plants. Shao, Guosheng,Chen, Mingxue,Wang, Weixia,Mon, Renxiang,Zhang, Guoping.

[2]Effect of Polysaccharides from Acanthopanax senticosus on Intestinal Mucosal Barrier of Escherichia coli Lipopolysaccharide Challenged Mice. Han, Jie,Xu, Yunhe,Yang, Di,Yu, Ning,Bai, Zishan,Bian, Lianquan,Xu, Yunhe,Yu, Ning.

[3]Polysaccharides from Acanthopanax senticosus enhances intestinal integrity through inhibiting TLR4/NF-B signaling pathways in lipopolysaccharide-challenged mice. Han, Jie,Liu, Lixia,Chen, Jing,Liu, Baoshan,Yang, Di,Shen, Guoshun,Yu, Ning.

[4]Effects of Dietary beta-1,3-Glucan on Expression of Immune-related Genes of Litopenaeus vannamei Exposed to Nitrite-N. Zhao, Hong-Xia,Cao, Jun-Ming,Huang, Yan-Hua,Li, Guo-Li,Lan, Han-Bing,Zhao, Hong-Xia,Wang, An-Li.

[5]The Eukaryote-Like Serine/Threonine Kinase STK Regulates the Growth and Metabolism of Zoonotic Streptococcus suis. Zhang, Chunyan,Sun, Wen,Dong, Mengmeng,Liu, Wanquan,Li, Lu,Xu, Zhuofei,Zhou, Rui,Tan, Meifang,Gao, Ting,Li, Lu,Xu, Zhuofei,Zhou, Rui. 2017

[6]Decreased energy synthesis is partially compensated by a switch to sucrose synthase pathway of sucrose degradation in restricted root of tomato plants. Shi, Kai,Fu, Li-Jun,Zhou, Yan-Hong,Yu, Jing-Quan,Yu, Jing-Quan,Dong, De-Kun.

[7]Cold pretreatment enhances microspore embryogenesis in oilseed rape (Brassica napus L.). Gu, HH,Hagberg, P,Zhou, WJ.

[8]Growth performance and nitrogen metabolism in weaned pigs fed diets containing different sources of starch. Li, T. J.,Huang, R. L.,Wu, G. Y.,Lin, Y. C.,Jiang, Z. Y.,Kong, X. F.,Chu, W. Y.,Zhang, Y. M.,Kang, P.,Hou, Z. P.,Fan, M. Z.,Liao, Y. P.,Yin, Y. L.. 2007

[9]Effects of Lactobacillus brevis preparation on growth performance, fecal microflora and serum profile in weaned pigs. Liu, H.,Ji, H. F.,Zhang, D. Y.,Wang, S. X.,Wang, J.,Shan, D. C.,Wang, Y. M..

[10]Effects of diosmectite-Lactobacillus acidophilus on growth performance, intestine microbiota, mucosal architecture of weaned pigs. Cao, Shuting,Jiao, Lefei,Lin, Fanghui,Xiao, Kan,Hu, Caihong,Wang, Li.

[11]Demographic analysis based on the growth parameter of sharks. Chen, PM,Yuan, WW.

[12]Humoral and cellular immune responses to Fasciola gigantica experimental infection in buffaloes. Zhang, WY,Moreau, E,Yang, BZ,Li, ZQ,Hope, JC,Howard, CJ,Huang, WY,Chauvin, A. 2006

[13]Effects of different cytokines on immune responses of rainbow trout in a virus DNA vaccination model. Cao, Yongsheng,Xu, Liming,Li, Shaowu,Wang, Di,Zhao, Jingzhuang,Liu, Hongbai,Lu, Tongyan,Cao, Yongsheng,Zhang, Qiya,Feng, Jian. 2017

[14]Infection of Goose with Genotype VIId Newcastle Disease Virus of Goose Origin Elicits Strong Immune Responses at Early Stage. Xu, Qianqian,Chen, Yuqiu,Zhao, Wenjun,Zhang, Tingting,Liu, Chenggang,Qi, Tianming,Ma, Deying,Xu, Qianqian,Chen, Yuqiu,Zhao, Wenjun,Zhang, Tingting,Liu, Chenggang,Qi, Tianming,Han, Zongxi,Shao, Yuhao,Liu, Shengwang. 2016

[15]Innate Immune Responses in ALV-J Infected Chicks and Chickens with Hemangioma In Vivo. Feng, Min,Xie, Tingting,Li, Zhenhui,Zhang, Xiquan,Feng, Min,Xie, Tingting,Li, Zhenhui,Zhang, Xiquan,Feng, Min,Xie, Tingting,Li, Zhenhui,Zhang, Xiquan,Dai, Manman,Shi, Meiqing. 2016

[16]Proteomic analysis of Fasciola hepatica excretory and secretory products (FhESPs) involved in interacting with host PBMCs and cytokines by shotgun LC-MS/MS. Liu, Qing,Huang, Si-Yang,Yue, Dong-Mei,Wang, Jin-Lei,Zhu, Xing-Quan,Liu, Qing,Wang, Yujian,Li, Xiangrui,Huang, Si-Yang,Zhu, Xing-Quan.

[17]Parapoxvirus orf virus infection induces an increase in interleukin-8, tumour necrosis factor-alpha, and decorin in goat skin fibroblast cells. Wang, Lingling,Lu, Bingzhou,Zheng, Haixue,Zhang, Keshan,Liu, Xiangtao.

[18]Characterisation and immunostimulatory activity of an alpha-(1 -> 6)-D-glucan from the cultured Armillariella tabescens mycelia. Yu, Mengyao,Yang, Zhirong,Zheng, Linyong,Xu, Xiaoyan,Yu, Mengyao,Zheng, Linyong. 2008

[19]Immunomodulation of RAW264.7 macrophages by GLIS, a proteopolysaccharide from Ganoderma lucidum. Ji, Zhe,Tang, Qingjiu,Zhang, Jinsong,Yang, Yan,Jia, Wei,Pan, Yingjie. 2007

[20]Dynamic expression of cytokine and transcription factor genes during experimental Fasciola gigantica infection in buffaloes. Shi, Wei,Wei, Zhi-Yong,Sheng, Zhao-An,Lu, Ke-Jing,Wang, Dong-Ying,Huang, Wei-Yi,Shi, Wei,Wei, Zhi-Yong,Zhang, Fu-Kai,Sheng, Zhao-An,Wang, Dong-Ying,Huang, Wei-Yi,Zhu, Xing-Quan,Elsheikha, Hany M.,Zhu, Xing-Quan. 2017

作者其他论文 更多>>

微信小程序