Model Predictive Control of Glucose Feeding for Fed-batch Candida utilis Biomass Production

文献类型: 外文期刊

第一作者: Guo Qingqiang

作者: Guo Qingqiang;Liu Guoli;Dong Nannan;Lin Jianqun;Lin Jianqiang;Guo Qingqiang;Li Qiqiang;Liu Guoli;Dong Nannan

作者机构:

关键词: Fermentation;model predictive control;mathematical model;on-line monitoring;Candida utilis

期刊名称:RESEARCH JOURNAL OF BIOTECHNOLOGY ( 影响因子:0.233; 五年影响因子:0.252 )

ISSN: 0973-6263

年卷期: 2013 年 8 卷 7 期

页码:

收录情况: SCI

摘要: In this work model predictive control (MPC) is used for control of glucose feeding rate of fed-batch culture for production of Candida utilis cell mass. A two layer hierarchical control system with the upper level for supervision and lower level for conventional control is designed which realizes automatic control, storage and refresh of kinetic model, data collection and on-line monitoring, data analysis and processing. The model stored in supervision computer is refreshed using genetic algorithm (GA) when the predictive error is over the limit. The results show that this method can control glucose concentration well and increase cell mass production effectively.

分类号:

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