Protection against vascular endothelial dysfunction by polyphenols in sea buckthorn berries in rats with hyperlipidemia

文献类型： 外文期刊

第一作者： Yang, Fang

作者： Yang, Fang;Suo, Yourui;Yang, Fang;Tong, Li;Yang, Fang;Suo, Yourui;Chen, Dongli

作者机构：

关键词： Vascular endothelial dysfunction;polyphenol;sea buckthorn berries;hyperlipidemia;protection

期刊名称：BIOSCIENCE TRENDS （ 影响因子：2.4； 五年影响因子：2.582 ）

ISSN： 1881-7815

年卷期： 2016 年 10 卷 3 期

页码：

收录情况： SCI

摘要： Chronic hyperlipemia increases the incidence of vascular endothelial dysfunction and can even induce cardiovascular disease. Sea buckthorn contains a host of bioactives such as flavonoids and polyphenols that can prevent the development of cardiovascular disease. The current study isolated active ingredients, polyphenols, from sea buckthorn berries (SVP) and orally administered SVP at a dose of 7-28 mg/kg. This treatment significantly reduced serum lipids, it enhanced the activity of antioxidant enzymes, and it decreased the level of serum TNF-alpha and IL-6. SVP also alleviate vascular impairment by decreasing the expression of eNOS, ICAM-1, and LOX-1 mRNA and proteins in aortas of rats with hyperlipidemia. Based on these findings, SVP has antioxidant action and it protects endothelium.

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