Genome-wide analysis of structural variants reveals genetic differences in Chinese pigs

文献类型： 外文期刊

第一作者： Yang, Ruifei

作者： Yang, Ruifei;Wang, Jing;Zhang, Chunyuan;Zhao, Yiqiang;Yang, Ruifei;Fang, Suyun;Wang, Jing;Zhang, Chunyuan;Zhang, Ran;Zhao, Yiqiang;Hu, Xiaoxiang;Li, Ning;Liu, Di;Hu, Xiaoxiang

作者机构：

期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）

ISSN： 1932-6203

年卷期： 2017 年 12 卷 10 期

页码：

收录情况： SCI

摘要： Pigs have experienced long-term selections, resulting in dramatic phenotypic changes. Structural variants (SVs) are reported to exert extensive impacts on phenotypic changes. We built a high resolution and informative SV map based on high-depth sequencing data from 66 Chinese domestic and wild pigs. We inferred the SV formation mechanisms in the pig genome and used SVs as materials to perform a population-level analysis. We detected the selection signals on chromosome X for northern Chinese domestic pigs, as well as the differentiated loci across the whole genome. Analysis showed that these loci differ between southern and northern Chinese domestic pigs. Our results based on SVs provide new insights into genetic differences in Chinese pigs.

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