Reference ranges for serum insulin-like growth factor I (IGF-I) in healthy Chinese adults

文献类型： 外文期刊

第一作者： Zhu, Huijuan

作者： Zhu, Huijuan;Gong, Fengying;Yang, Hongbo;Xu, Ke;Chen, Shi;Wang, Linjie;Pan, Hui;Zhu, Huijuan;Xu, Yuan;Gong, Fengying;Shan, Guangliang;Yang, Hongbo;Xu, Ke;Zhang, Dianxi;Cheng, Xinqi;Chen, Shi;Wang, Linjie;Pan, Hui;Xu, Yuan;Shan, Guangliang;Zhang, Dianxi;Cheng, Xinqi;Zhang, Zhihao;Zhang, Zhihao

作者机构：

期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）

ISSN： 1932-6203

年卷期： 2017 年 12 卷 10 期

页码：

收录情况： SCI

摘要： Purpose To determine serum insulin-like growth factor 1 (IGF-I) levels in healthy Chinese adults, establish reference ranges for serum IGF-I levels and observe the effects of age, sex, body mass index (BMI) and geographical region on serum IGF-I levels. Methods In total, 2791 healthy adults (1339 males and 1452 females) from the north (Beijing) and south (Guizhou Province) of China were recruited following a questionnaire survey, physical examination and laboratory examination. Both sexes were divided into 13 groups according to age (18, 19, 20-24, 25-29, 30-34, 35-39, 40-44, 45-49, 50-54, 55-59, 60-64, 65-69 and -70 years). The serum IGF-I levels were measured by performing a chemiluminescent assay (Immulite 2000 (R)), and the LMS (Lambda-Mu-Sigma) method was applied to construct smooth centile curves of age-specific IGF-I levels. Results Serum IGF-I levels in the adults gradually decreased with increasing age from 18 to 70 years in both the male and female participants. Although the decrease in the level of IGF-1 was more pronounced in females than in males, no significant difference was observed between the sexes, except in the 60-to 64-year-old age group (P = 0.0329). The multiple linear regression model showed that there was an inverse relationship between the serum IGF-I level and BMI (P<0.001), and the serum IGF-I level in the Guizhou population was higher than that in the Beijing population (P<0.05). Conclusion The normal reference ranges for age- and sex-specific serum IGF-I levels were established for the first time in a large sample of Chinese adults. The serum IGF-I levels were significantly influenced by age, BMI and geographical region.

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