A Phytophthora infestans RXLR effector targets plant PP1c isoforms that promote late blight disease

文献类型： 外文期刊

第一作者： Boevink, Petra C.

作者： Boevink, Petra C.;Wang, Xiaodan;Naqvi, Shaista;Armstrong, Miles R.;Hein, Ingo;Gilroy, Eleanor M.;Birch, Paul R. J.;Wang, Xiaodan;McLellan, Hazel;He, Qin;Armstrong, Miles R.;Birch, Paul R. J.;Wang, Xiaodan;He, Qin;Zhang, Wei;Tian, Zhendong

作者机构：

期刊名称：NATURE COMMUNICATIONS （ 影响因子：14.919； 五年影响因子：15.805 ）

ISSN： 2041-1723

年卷期： 2016 年 7 卷

页码：

收录情况： SCI

摘要： Plant pathogens deliver effectors to alter host processes. Knowledge of how effectors target and manipulate host proteins is critical to understand crop disease. Here, we show that in planta expression of the RXLR effector Pi04314 enhances leaf colonization by Phytophthora infestans via activity in the host nucleus and attenuates induction of jasmonic and salicylic acid-responsive genes. Pi04314 interacts with three host protein phosphatase 1 catalytic (PP1c) isoforms, causing their re-localization from the nucleolus to the nucleoplasm. Re-localization of PP1c-1 also occurs during infection and is dependent on an R/KVxF motif in the effector. Silencing the PP1c isoforms or overexpression of a phosphatase-dead PP1c-1 mutant attenuates infection, demonstrating that host PP1c activity is required for disease. Moreover, expression of PP1c-1mut abolishes enhanced leaf colonization mediated by in planta Pi04314 expression. We argue that PP1c isoforms are susceptibility factors forming holoenzymes with Pi04314 to promote late blight disease.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序