Two Antimycin A Analogues from Marine-Derived Actinomycete Streptomyces lusitanus

文献类型： 外文期刊

第一作者： Han, Zhuang

作者： Han, Zhuang;Xu, Ying;Liu, Lingli;Li, Yongxin;Huang, Xiangzhong;Qian, Peiyuan;Han, Zhuang;Qi, Shuhua;Han, Zhuang;McConnell, Oliver

作者机构：

关键词： marine-derived actinomycete;Streptomyces lusitanus;antibacterial;antimycin B

期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）

ISSN： 1660-3397

年卷期： 2012 年 10 卷 3 期

页码：

收录情况： SCI

摘要： Two new antimycin A analogues, antimycin B1 and B2 (1-2), were isolated from a spent broth of a marine-derived bacterium, Streptomyces lusitanus. The structures of 1 and 2 were established on the basis of spectroscopic analyses and chemical methods. The isolated compounds were tested for their anti-bacterial potency. Compound 1 was found to be inactive against the bacteria Bacillus subtilis, Staphyloccocus aureus, and Loktanella hongkongensis. Compound 2 showed antibacterial activities against S. aureus and L. hongkongensis with MIC values of 32.0 and 8.0 mu g/mL, respectively.

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