Investigation of fermentation conditions and optimization of medium for taxol production from taxol-producing fungi

文献类型： 外文期刊

第一作者： Zhao, Kai

作者： Zhao, Kai;Li, Zhugang;Ge, Nan;Li, Xiuliang;Wang, Xin;Zhou, Dongpo;Zhao, Kai

作者机构：

关键词： Taxol-producing fungi;taxol;fermentation;medium optimization

期刊名称：JOURNAL OF MEDICINAL PLANTS RESEARCH （ 影响因子：0.879； 五年影响因子：0.877 ）

ISSN： 1996-0875

年卷期： 2011 年 5 卷 29 期

页码：

收录情况： SCI

摘要： The monofactor-design test was used to optimize the culture conditions for the fermentation of taxol-producing fungus UV40-19 as follows: the initial pH value of the fermentation broth was 5.5, the culture temperature was 25 degrees C, and the rotational speed was 150 r/min. Orthogonal design was used to optimize the fermentation medium of taxol-producing fungi. The optimized medium increased the yield of taxol to 456.24 +/- 2.83 mu g/L, which is 115% of the yield obtained with the modified S-7 medium. The results showed a great potential for producing taxol on an industrial scale, which would lead to significant economic and social benefit in the future.

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