Metabolomic and regular analysis reveal phytotoxic mechanisms of sterigmatocystin in Amaranthus retroflexus L.

文献类型： 外文期刊

第一作者： Zhao, Dong-Lin

作者： Zhao, Dong-Lin;Sun, Rui-Xue;Wang, Mei;Zhang, Xi-Fen;Li, Yi-Qiang;Ma, Si-Qi;Zhang, Cheng-Sheng;Han, Xiao-Bin;Wang, Xian-Bo;Wan, Jun;Liu, Jing

作者机构：

关键词： Sterigmatocystin; Phytotoxic mechanisms; Amino acid biosynthesis; Cell membrane alterations; Oxidative damage

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.8； 五年影响因子：6.9 ）

ISSN： 0147-6513

年卷期： 2022 年 247 卷

页码：

收录情况： SCI

摘要： Sterigmatocystin (STE) is a common hepatotoxic and nephrotoxic contaminant in cereals, however, its phyto-toxicity and mechanisms are poorly understood. Here, the phytotoxic mechanisms of STE were investigated via the metabolomics of Amaranthus retroflexus L. A total of 140 and 113 differential metabolites were detected in the leaves and stems, respectively, among which amino acids, lipids, and phenolic compounds were significantly perturbed. Valine, leucine, isoleucine, and lysine biosynthesis were affected by STE. These metabolic responses revealed that STE might be toxic to plants by altering the plasma membrane and inducing oxidative damage, which was verified by measuring the relative electrical conductivity and quantification of reactive oxygen species. The elevated amino acids, as well as the decreased of D-sedoheptuiose-7-phosphate indicated increased proteolysis and carbohydrate metabolism restriction. Furthermore, the IAA level also decreased. This study provides a better understanding of the impacts of STE on the public health, environment and food security.

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