Genome architecture and tetrasomic inheritance of autotetraploid potato

文献类型： 外文期刊

第一作者： Bao, Zhigui

作者： Bao, Zhigui;Wang, Pei;Peng, Zhen;Cheng, Lin;Li, Hongbo;Zhang, Zhiyang;Li, Yuying;Huang, Wu;Zhang, Chunzhi;Huang, Sanwen;Zhou, Qian;Li, Canhui;Ye, Mingwang;Li, Guangcun;Li, Hongbo;Jacobsen, Evert;Bachem, Christian W. B.;Dong, Daofeng;Cheng, Zhukuan;VanderZaag, Peter;Dong, Suomeng;Dong, Suomeng;Zhou, Qian

作者机构：

关键词： potato genome; polyploid genome; haplotype-resolved assembly; haplotype diversity; potato centromere

期刊名称：MOLECULAR PLANT （ 影响因子：21.949； 五年影响因子：19.617 ）

ISSN： 1674-2052

年卷期： 2022 年 15 卷 7 期

页码：

收录情况： SCI

摘要： Potato (Solanum tuberosum) is the most consumed non-cereal food crop. Most commercial potato cultivars are autotetraploids with highly heterozygous genomes, severely hampering genetic analyses and improvement. By leveraging the state-of-the-art sequencing technologies and polyploid graph binning, we achieved a chromosome-scale, haplotype-resolved genome assembly of a cultivated potato, Cooperation-88 (C88). Intra-haplotype comparative analyses revealed extensive sequence and expression differences in this tetraploid genome. We identified haplotype-specific pericentromeres on chromosomes, suggesting a distinct evolutionary trajectory of potato homologous centromeres. Furthermore, we detected double reduction events that are unevenly distributed on haplotypes in 1021 of 1034 selfing progeny, a feature of autopolyploid inheritance. By distinguishing maternal and paternal haplotype sets in C88, we simulated the origin of heterosis in cultivated tetraploid with a survey of 3110 tetra-allelic loci with deleterious mutations, which were masked in the heterozygous condition by two parents. This study provides insights into the genomic architecture of autopolyploids and will guide their breeding.

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[1]Genome architecture and tetrasomic inheritance of autotetraploid potato. Bao, Zhigui,Wang, Pei,Peng, Zhen,Cheng, Lin,Li, Hongbo,Zhang, Zhiyang,Li, Yuying,Huang, Wu,Zhang, Chunzhi,Huang, Sanwen,Zhou, Qian,Li, Canhui,Ye, Mingwang,Li, Guangcun,Li, Hongbo,Jacobsen, Evert,Bachem, Christian W. B.,Dong, Daofeng,Cheng, Zhukuan,VanderZaag, Peter,Dong, Suomeng,Dong, Suomeng,Zhou, Qian. 2022

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