A Brief Review of Aptamer-Based Biosensors in Recent Years

文献类型： 外文期刊

第一作者： Wang, Wenjing

作者： Wang, Wenjing;He, Yumin;He, Suxiang;Feng, Zemeng;Yin, Yulong;Wang, Wenjing;He, Yumin;He, Suxiang;Deng, Lei;Wang, Hui;Xiong, Benhai;Cao, Zhong

作者机构：

关键词： peptide; nucleic acid; aptamer; biosensor; review

期刊名称：BIOSENSORS-BASEL （ 影响因子：5.6； 五年影响因子：5.7 ）

ISSN：

年卷期： 2025 年 15 卷 2 期

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收录情况： SCI

摘要： Aptamers have recently become novel probes for biosensors because of their good biocompatibility, strong specificity, and high sensitivity. Biosensors based on peptides or nucleic acid aptamers are used in implantable and wearable devices owing to their ease of synthesis and economic efficiency. Simultaneously, amphoteric ionic peptides are being explored as antifouling layers for biosensors resistant to interference from extraneous proteins in serum. Thus, this paper reviews recently developed aptamer-based biosensors and introduces peptide- and nucleic acid-based biosensors, while focusing on the three primary classes of biosensors: electrochemical sensors, fluorescent or colorimetric biosensors, and electroluminescent sensors. Furthermore, we summarize their general construction strategies, describe specific electrochemical sensors that use peptides as an antipollution layer, and elucidate their advantages.

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